AI Article Synopsis
- A new bioactive cyclohexapeptide, named diandrine C, was synthesized from a combination of a tetrapeptide and a dipeptide using a specific coupling agent and subsequent cyclization.
- The structure of diandrine C was confirmed through various chemical and spectroscopic analyses.
- Bioevaluation showed that it has strong antimicrobial activity against certain Gram-negative bacteria and moderate to good anthelmintic activity against three earthworm species at specified concentrations.
Article Abstract
A new bioactive proline-rich cyclohexapeptide - diandrine C (), previously isolated from whole plant of (Caryophyllaceae), was synthesized through coupling reactions of tetrapeptide unit Boc-Gly--Pro--Tyr--Trp-OH with dipeptide unit -Pro-Gly-OMe using -diisopropylcarbodiimide (DIPC) as the coupling agent, followed by cyclization of linear hexapeptide unit under alkaline condition. Structure of cyclohexapeptide was confirmed by means of chemical, and spectroscopic analyses and also was screened for its antimicrobial and anthelmintic properties. Bioevaluation results indicated that the newly synthesized hexacyclopeptide exhibited potent antimicrobial activity against Gram-negative bacteria , and pathogenic at 6 μg/mL. Moderate to good level of antihelmintic activity against three earthworm species , and was also observed at concentration of 2 mg/mL.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706746 | PMC |
| http://dx.doi.org/10.22037/ijpr.2019.1100643 | DOI Listing |
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