Synthesis and antifungal activity of novel pyrazolines and isoxazolines derived from cuminaldehyde.

Two series of novel cuminaldehyde derivatives containing pyrazoline and isoxazoline moieties have been designed and synthesized. All of the compounds were characterized H-NMR,C-NMR, and HRMS. The antifungal activities were evaluated against six plant-pathogenic fungi. 3-(2-Fluorophenyl)-5-(4-isopropylphenyl) isoxazoline () and 1-acetyl-3-(2-fluorophenyl)-5-(4-isopropylphenyl)-2-pyrazoline () displayed higher antifungal activities than commercial fungicides against , and . The title compounds ( and ) with strong antifungal activities are worth being further evaluated and in the field.