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Sensitive and selective determination of upadacitinib using a custom-designed electrochemical sensor based on ZnO nanoparticle-assisted molecularly imprinted polymer.
Anal Bioanal Chem
November 2024
Department of Analytical Chemistry, Ankara University, Faculty of Pharmacy, Ankara, Türkiye.
Upadacitinib (UPA) is a selective and reversible oral Janus kinase (JAK) 1 inhibitor and is of great importance in treating inflammatory bowel disease (Zheng et al., Int Immunopharmacol 126:111229, 2024; Foy et al., JAAD Case Rep 42:20-22, 2023).
View Article and Find Full Text PDFMAP3K19 Affects TWEAK-Induced Response in Cultured Bronchial Epithelial Cells and Regulates Allergic Airway Inflammation in an Asthma Murine Model.
Curr Issues Mol Biol
November 2023
Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Article Synopsis
- The study explores the role of MAP3K19 in the epithelial-mesenchymal transition (EMT) and asthma, focusing on its uncertain involvement in these processes.
- Researchers used a bronchial epithelial cell line and MAP3K19-deficient mice to examine how knocking down MAP3K19 affects cytokine production and airway inflammation.
- Results showed that MAP3K19 reduces TWEAK-stimulated responses and allergic airway inflammation, suggesting its potential as a regulatory factor in asthma.
Melanocyte progenitor cells reside in human subcutaneous adipose tissue.
PLoS One
December 2021
Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
Based on the assumption that some progenitor cells in an organ might reside in neighboring adipose tissue, we investigated whether melanocyte progenitor cells reside in human subcutaneous adipose tissue. First, we examined the expression of human melanoma black 45 (HMB45) and microphthalmia-associated transcription factor (MITF) in undifferentiated adipose-derived stem cells (ADSCs) by immunostaining, RT-PCR, and western blotting. These two markers were detected in undifferentiated ADSCs, and their expression levels were increased in differentiated ADSCs in melanocyte-specific culture medium.
View Article and Find Full Text PDFPU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome Regulating Its Expression in Human Macrophages.
Front Immunol
September 2021
Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Katsushika-Ku, Japan.
NLRP3 inflammasomes play crucial roles in the initiation of host defense by converting pro-Caspase-1 to mature Caspase-1, which in turn processes immature IL-1β and IL-18 into their biologically active forms. Although NLRP3 expression is restricted to monocytic lineages such as monocytes, macrophages, and dendritic cells, the mechanisms determining the lineage-specific expression of NLRP3 remain largely unknown. In this study, we investigated the transcription factors involved in cell-type-specific transcription of .
View Article and Find Full Text PDFReal-World Experience with Benralizumab in Patients with Severe Eosinophilic Asthma: A Case Series.
J Asthma Allergy
February 2021
Department of Health Sciences, Respiratory Unit, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
Purpose: Severe eosinophilic asthma (SEA) is characterized by high eosinophilia, severe symptoms, important comorbidities, frequent exacerbations, and poor asthma control. Benralizumab, targeting the interleukin-5 receptor alpha, proved effective in inducing rapid eosinophil depletion and amelioration of symptoms and lung function; it also allowed to reduce exacerbations and the use of oral corticosteroids (OCS). The present case series, spanning different subtypes of SEA, aimed at expanding the real-world experience with benralizumab in Italy.
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