AI Article Synopsis
- Non-ablative pulsed focused ultrasound (pFUS) activates immune responses in tumors without causing thermal damage, but optimal parameters for different tumor types are still unclear.
- pFUS at 6 MPa caused DNA damage in tumor cells and modified inflammatory cytokine levels, suggesting it may enhance anti-tumor immunity in certain cases.
- The variability in responses between different tumor types indicates that more research is needed to determine the effectiveness of pFUS as a cancer treatment.
Article Abstract
Non-ablative pulsed focused ultrasound (pFUS) targets non-thermal forces that activate local molecular and cellular immune responses. Optimal parameters to stimulate immunotherapeutic tumor microenvironments (TME) and responses in different tumor types remain uninvestigated. Flank B16 murine melanoma and 4T1 breast tumors received 1 MHz pFUS at 1-8 MPa peak negative pressures (PNP) and were analyzed 24 hr post-sonication. Necrosis or hemorrhage were unaltered in both tumors, but pFUS induced DNA strand breaks in tumor cells at PNP ≥6 MPa. pFUS at >4 MPa suppressed anti-inflammatory cytokines in B16 tumors. pFUS to 4T1 tumors decreased anti-inflammatory cytokines and increased pro-inflammatory cytokines and cell adhesion molecules. pFUS at 6 MPa increased calreticulin and alterations in check-point proteins along with tumoral and splenic immune cell changes that could be consistent with a shift towards an anti-TME. pFUS-induced TME alterations shows promise in generating anti-tumor immune responses, but non-uniform responses between tumor types require additional investigation to assess pFUS as a suitable anti-tumor therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456468 | PMC |
| http://dx.doi.org/10.1016/j.ultrasmedbio.2019.08.014 | DOI Listing |
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