Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2's functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH9 is a new strategy to tackle metabolism-addicted tumors.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736202 | PMC |
| http://dx.doi.org/10.1080/23723556.2019.1644599 | DOI Listing |
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