AI Article Synopsis
- The study investigates tetranectin mRNA expression levels to improve early detection and classification of oral squamous cell carcinoma (OSCC) using saliva samples from patients and healthy individuals.
- Researchers employed semiquantitative PCR and real-time PCR to compare mRNA levels, finding that OSCC patients have significantly lower levels than healthy individuals (P≤0.05).
- This research aims to enhance cancer detection methods, as current histological techniques often diagnose OSCC at later stages, and tetranectin serves as a valuable protein biomarker for various cancers.
Article Abstract
The current study is focused on determining the mRNA expression levels of tetranectin, to detect oral squamous cell carcinoma (OSCC) and thus aiding in its classification at an early stage. RNA was isolated and cDNA synthesis was performed from the saliva samples of the patients and healthy individuals. A semiquantitative PCR based analysis was performed prior to quantitative and expression based analysis using Real time PCR. The study showed that the mRNA levels are much lesser in patients suffering from dysplastic and metastatic tumors as compared to healthy individuals (P≤0.05). This study can be a breakthrough in medical and dentistry studies. One of the most common malignant carcinomas, OSCC is a type of cancer of the mouth. Though surgical methods have been quite effective in delaying the metastasis, the detection methods using histology parameters are not very efficient and the disease is diagnosed generally in the last stages of the cancer. Tetranectin is a protein biomarker which has been used for detection of several cancers including oral cancer where the protein quantity is calculated.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510212 | PMC |
| http://dx.doi.org/10.22099/mbrc.2019.31544.1365 | DOI Listing |
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