AI Article Synopsis
- The study aimed to investigate the role of the nuclear pore membrane protein POM121 in oral squamous cell carcinoma (OSCC) and its underlying mechanisms.
- Results showed that POM121 mRNA and protein levels were significantly higher in OSCC tissues than in normal tissues, with high expression linked to worse patient survival and advanced disease stages.
- Bioinformatics suggested that POM121 may influence OSCC via the hedgehog and/or p53 signaling pathways, indicating that targeting POM121 could lead to new diagnostic and treatment options.
Article Abstract
The aim of this study was to confirm the role of nuclear pore membrane protein 121(POM121) in oral squamous cell carcinoma and to explore the underlying mechanism. POM121mRNA and protein expressions were evaluated in OSCC tissues and normal oral tissues by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry. The relationship between POM121 expression and clinical characteristics was analyzed. Bioinformatics analysis was performed to explore the possible mechanisms how POM121 affected OSCC. We confirmed that POM121 mRNA expression in OSCC tissues was significantly higher than that in non-tumorous tissues, as was POM121 protein expression. POM121 expression was associated with distant metastasis and TNM stage. Multivariate analysis confirmed POM121 expression as an independent prognostic factor for OSCC patients. OSCC patients with high POM121 expression had a worse overall survival (OS) compared with patients with low POM121 expression. Bioinformatics analysis indicated POM121 may regulate OSCC through hedgehog and /or p53 signaling pathway. Targeting of POM121 expression levels could provide new diagnostic and therapeutic strategies for OSCC patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746134 | PMC |
| http://dx.doi.org/10.7150/jca.33368 | DOI Listing |
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