Myasthenia Gravis Presenting as Lutz Posterior Internuclear Ophthalmoplegia.

Neuroophthalmology

Ophthalmology & Visual Sciences, Neurology, and Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Published: August 2019

AI Article Synopsis

  • Myasthenia gravis can resemble central nervous system disorders, making it crucial to consider it when diagnosing pupil-sparing eye movement issues.
  • An unusual case of myasthenia gravis presented as bilateral internuclear ophthalmoplegia (INO), affecting the ability to abduct the eyes.
  • This specific type of INO is sometimes called Lutz posterior INO or reverse INO.

Article Abstract

Myasthenia gravis can mimic central neurological disorders and should be considered in the differential diagnosis of any form of pupil-sparing ophthalmoplegia. We report an unusual manifestation of myasthenia gravis presenting as bilateral internuclear ophthalmoplegia (INO) of abduction, sometimes referred to as Lutz posterior INO (or reverse INO).

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736120PMC
http://dx.doi.org/10.1080/01658107.2018.1489859DOI Listing

Publication Analysis

Top Keywords

myasthenia gravis
12
gravis presenting
8
lutz posterior
8
internuclear ophthalmoplegia
8
presenting lutz
4
posterior internuclear
4
ophthalmoplegia myasthenia
4
gravis mimic
4
mimic central
4
central neurological
4

Similar Publications

International consensus guidance and Japanese clinical guidelines for myasthenia gravis (MG) recommend achieving minimal manifestations or better status (MM-or-better) as the severity component of the treatment goal. However, the subjective nature of determining MM can result in ambiguity regarding this category in clinical practice and clinical trials. This study analyzed severity metrics in a large number of MG patients to propose criteria for MM-or-better.

View Article and Find Full Text PDF

Objective: Myasthenia gravis (MG), a low-prevalence autoimmune disorder characterized by clinical heterogeneity and unpredictable disease fluctuations, presents significant risks of acute exacerbations requiring intensive care. These crises contribute substantially to patient morbidity and mortality. This study aimed to develop and validate machine-learning models for predicting intensive care unit (ICU) admission risk among patients with MG-related disease instability.

View Article and Find Full Text PDF

PD-1/PD-L1 inhibitors related adverse events: A bibliometric analysis from 2014 to 2024.

Hum Vaccin Immunother

December 2025

Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Programmed cell death-1 (PD-1) inhibitors and programmed cell death ligand 1 (PD-L1) inhibitors are considered effective alternatives for the primary treatment of recurrent metastatic cancers. However, they can induce various adverse events affecting multiple organ systems, potentially diminishing patients' quality of life, and even leading to treatment interruptions. Adverse events related to PD-1/PD-L1 inhibitors differ from those associated with CTLA-4 inhibitors and are more commonly observed in the treatment of solid tumors.

View Article and Find Full Text PDF

Myasthenia gravis (MG) presents with symptoms that significantly affect patients' daily lives. Long-term MG therapies may lead to substantial side effects, predominantly due to prolonged immune suppression. Sirt6, which plays a vital role in maintaining cellular homeostasis and is recognised for its involvement in cytokine production in immune cells, has not yet been explored in relation to MG.

View Article and Find Full Text PDF

This case report describes a woman in her 50s with a rare coexistence of neuromyelitis optica spectrum disorder (NMOSD) and myasthenia gravis (MG), highlighting the diagnostic challenges and therapeutic considerations. Initially diagnosed with acetylcholine receptor antibody-positive MG, she later developed progressive visual impairment, leading to a diagnosis of NMOSD. Rituximab treatment was effective in managing both conditions, demonstrating the benefits of targeted therapies in reducing complications related to polypharmacy.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!