AI Article Synopsis
- Birth weight (BW) is generally higher for babies conceived through frozen embryo transfer (FET) compared to fresh embryo transfer, and the study aims to investigate whether the freezing-thawing process contributes to this difference.
- The study analyzed two groups: one with older siblings conceived via fresh embryos and younger siblings via frozen embryos, and another with siblings both conceived through FET from the same embryo cohort.
- Results showed that the average BW for FET babies was significantly higher than for fresh, suggesting that cryopreservation plays a critical role in BW variation, independent of sibling parity.
Article Abstract
Birth weight (BW) is higher after frozen embryo transfer (FET) than after fresh embryo replacement. No study has compared the BW of siblings conceived using the same oocyte/embryo cohort. The aim of this study was to determine whether the freezing-thawing procedure is involved in such difference. Multicenter study at Montpellier University Hospital, Clinique Ovo, Canada and Grenoble-Alpes University Hospital. The first cohort (Fresh/FET) included in vitro fertilization (IVF) cycles where the older was born after fresh embryo transfer (n = 158) and the younger after transfer of frozen supernumerary embryos (n = 158). The second cohort (FET/FET) included IVF cycles where older and younger were born after FET of embryos from the same cohort. The mean adjusted BW of the FET group was higher than that of the fresh group (3508.9 ± 452.4 g vs 3237.7 ± 463.3 g; p < 0.01). In the FET/FET cohort, the mean adjusted BW was higher for the younger by 93.1 g but this difference is not significant (3430.2 ± 347.6 g vs 3337.1 ± 391.9 g; p = 0.3789). Our results strongly suggest that cryopreservation is directly involved in the BW variation. Comparing BW difference between Fresh/FET cohort and FET/FET one, it suggests that parity is not the only responsible, increasing the role of cryopreservation step in BW variation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746979 | PMC |
| http://dx.doi.org/10.1038/s41598-019-49708-7 | DOI Listing |
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