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New evidence for baroreflex and respiratory chemoreflex mediated cerebral sympathetic activation in humans.
J Appl Physiol (1985)
December 2024
Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
The brain is highly innervated by sympathetic nerve fibres; however, their physiological purpose is poorly understood. We hypothesized that unilateral cerebral norepinephrine (NE) spillover, an index of cerebral sympathetic nerve activity (SNA), would be elevated when engaging the baroreflex [via lower-body negative pressure (LBNP; -20 and -40 Torr)] and respiratory chemoreflexes [via carbon dioxide (CO) administration (+8 Torr)], independently, and in combination. Twelve young and healthy participants (5 females) underwent simultaneous blood sampling from the right radial artery and internal jugular vein.
View Article and Find Full Text PDFDo Exercise and Magnesium Sulfate Improve Infertility Caused by Lithium Carbonate in Male Rats?
Adv Biomed Res
November 2024
Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Background: Lithium (Li) is widely used in the treatment of bipolar disorder, but it may lead to toxicity in the reproductive system. Considering the harmful effect of Li consumption on fertility and the positive effect of magnesium sulfate (MgSo) and moderate-intensity training (MIT) on improving the quality of men's sperm, the current research was conducted to determine the impact of MIT and MgSo on infertility caused by Li.
Materials And Methods: Seventy-two male rats were divided into 12 groups, control, Li10 mg/kg/day/ip, MgSo 80 mg/kg/day/ip; MIT; Li40 mg/kg/day/ip; Li10+MgSo; Li10+MIT; Li10+MgSo+MIT; Li40+MgSo; Li40+MIT; Li40+MgSo+MIT.
Spotlight on the 2024 ESC/EACTS management of atrial fibrillation guidelines: 10 novel key aspects.
Europace
December 2024
Department of Cardiology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Atrial fibrillation (AF) remains the most common cardiac arrhythmia worldwide and is associated with significant morbidity and mortality. The European Society of Cardiology (ESC)/European Association for Cardio-Thoracic Surgery (EACTS) have recently released the 2024 guidelines for the management of AF. This review highlights 10 novel aspects of the ESC/EACTS 2024 Guidelines.
View Article and Find Full Text PDFStroke Volume Augmentation Improves with PH-Targeted Therapy in Patients with Exercise-Induced Pulmonary Hypertension.
Respir Med
December 2024
University of California, Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, 9300 Campus Point Drive, MC #7381, La Jolla, San Diego, CA 92037. Electronic address:
Unlabelled: Exercise-induced pulmonary arterial hypertension (EiPH) is often treated with off-label use of pulmonary arterial hypertension-targeted therapy (PH-targeted therapy). Most measures of PAH severity are normal in patients with EiPH, posing challenges in evaluating for physiological improvement in patients treated for EiPH. In this study, we used non-invasive cardiopulmonary exercise testing (CPET) to assess for objective improvement in patients treated for EiPH.
View Article and Find Full Text PDFLeucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors.
Nat Biomed Eng
December 2024
Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Resistance to chimaeric antigen receptor (CAR) T cell therapy develops through multiple mechanisms, most notably antigen loss and tumour-induced immune suppression. It has been suggested that T cells expressing multiple CARs may overcome the resistance of tumours and that T cells expressing receptors that switch inhibitory immune-checkpoint signals into costimulatory signals may enhance the activity of the T cells in the tumour microenvironment. However, engineering multiple features into a single T cell product is difficult because of the transgene-packaging constraints of current gene-delivery vectors.
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