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In this issue of Cancer Cell, Parvin and colleagues identify the expression of LMO2 as a biomarker for DNA repair defects in lymphomas. Using isogenic cell lines and xenografts, the authors show that expression of LMO2 predicts sensitivity to PARP inhibition, especially in combination with genotoxic therapy.
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| http://dx.doi.org/10.1016/j.ccell.2019.08.011 | DOI Listing |
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Article Synopsis
- The study aimed to analyze clinical traits and survival of patients with diffuse large B-cell lymphoma (DLBCL), identify key prognostic markers, and create a nomogram model for predicting outcomes.
- Researchers examined 137 DLBCL patients over five years, using immunohistochemistry to measure specific proteins, and applied statistical methods to identify significant prognostic factors for survival.
- Results indicated that positive expression of LMO2 correlated with longer overall survival times, while a nomogram including various clinical factors showed strong predictive accuracy for 4-year survival rates.
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