AI Article Synopsis
- Hypermethylation in gene regulatory regions is linked to various cancers, prompting research into its implications for lung cancer detection.
- The study utilized GLAD-PCR assay to identify specific methylated sites in 13 downregulated genes within lung cancer tissue samples.
- Findings reveal that certain RCGY sites in genes like MYF6 and TERT show promising diagnostic potential, achieving 80% sensitivity and 88% specificity for lung cancer detection compared to normal tissues.
Article Abstract
Hypermethylation of the gene regulatory regions are common for many cancer diseases. In this work we applied GLAD-PCR assay for identificating of the aberrantly methylated RCGY sites in the regulatory regions of some downregulated genes in tissue samples of lung cancer (LC). This list includes EFEMP1, EPHA5, HOXA5, HOXA9, LHX1, MYF6, NID2, OTX1, PAX9, RARB, RASSF1A, RXRG, SIX6, SKOR1 and TERT genes. The results of DNA samples from 40 cancer and 25 normal lung tissues showed a good diagnostic potential of selected RCGY sites in regulatory regions of MYF6, SIX6, RXRG, LHX1, RASSF1A and TERT genes with relatively high sensitivity (80.0 %) and specificity (88.0 %) of LC detection in tumor DNA.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754573 | PMC |
| http://dx.doi.org/10.3779/j.issn.1009-3419.2019.09.01 | DOI Listing |
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