Stroke is a multifactorial disease and a consequence of morbidities of diabetes, obesity, hypertension, and heart diseases. Leptin is a major adipokine that regulates weight balance and energy homeostasis, the level of which has been considered as an indicator of acute ischemic stroke. In the present study, we confirmed the high level of leptin and noradrenaline in stroke patients and mouse models as well as oxygen-glucose deprivation (OGD) primary cerebral neurons. Leptin administration increased noradrenaline concentration and dopamine β-monooxygenase (DBH) but decreased noradrenaline transporter (NET) expression in primary cerebral neurons. Moreover, induced noradrenaline concentration, DBH activity, and inhibited NET were blunted by TG101348 (JAK2 inhibitor). JAK2 silencing also abolished the effects of leptin on noradrenaline metabolism.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1691/ph.2019.9379 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Cameroon Western Regions high-fat diet (MACAPOS 2) induces visceral obesity in rat.
Heliyon
January 2025
Laboratory of Human Metabolism and Non-Communicable Diseases, Research Centre on Health and Priority Pathologies, (IMPM), P.O. Box. 13033, Yaoundé, Cameroon.
The prevalence of obesity increases yearly in the world. The traditional local diet of the Western Regions of Cameroon was suspected to be the main contributor to the high prevalence of obesity in these Regions. This study aimed to evaluate the effects of a Cameroon-comparable fat diet on visceral obesity in rats.
View Article and Find Full Text PDFRamulus Mori (Sangzhi) alkaloids ameliorate high-fat diet induced obesity in rats by modulating gut microbiota and bile acid metabolism.
Front Endocrinol (Lausanne)
December 2024
Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Objective: The objective of this study is to investigate the ability of Ramulus Mori (Sangzhi) alkaloid tablets (SZ-A) to ameliorate obesity and lipid metabolism disorders in rats subjected to a high-fat diet (HFD) through metagenomics, untargeted lipidomics, targeted metabolism of bile acid (BA), and BA pathways, providing a novel perspective on the management of metabolic disorders.
Methods: In this research, HFD-fed rats were concurrently administered SZ-A orally. We measured changes in body weight (BW), blood lipid profiles, and liver function to assess therapeutic effects.
Body Composition, Adipocytokine, and Metabolic Parameters in Men With Congenital Hypogonadotropic Hypogonadism.
Clin Endocrinol (Oxf)
January 2025
Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Objective: This study aimed to evaluate the long-term effects of hormone therapies on the body composition, adipokines and metabolic parameters of adult men with congenital hypogonadotropic hypogonadism (CHH).
Methods: Sixty-six patients with CHH and 21 healthy controls were recruited. Patients were divided into untreated (n = 33) and treated (n = 33) groups based on hormone therapy history.
Obesity modifies the association between abnormal glucose metabolism and atrial fibrillation in older adults: A community-based longitudinal and prospective cohort study.
Hellenic J Cardiol
January 2025
Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China. Electronic address:
Purpose: To investigate the modifying role of obesity in the association between abnormal glucose metabolism and atrial fibrillation (AF) risk in older individuals.
Methods: From April 2007 to November 2011, 11663 participants aged ≥60 years were enrolled in Shandong area. Glucose metabolic status were determined using fasting plasma glucose and hemoglobin A1c levels, obesity determined using body mass index (BMI), waist-to-hip ratio (WHR), and visceral fat area (VFA).
Bone dynamics in zebrafish on low- and high-frequency diets.
Comp Biochem Physiol B Biochem Mol Biol
January 2025
University of Akron, Department of Biology, Akron, OH, USA. Electronic address:
Zebrafish (Danio rerio) were fed high and low-frequency diets over 40 days to assess the effect of diet on bone parameters. Fish fed 3×/day (High) were significantly greater in total weight and length vs. fish fed 2×/week (Low; <0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!