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Enantioenriched 1-Tetralones via Rhodium-Catalyzed Arylative Cascade Desymmetrization/Acylation of Alkynylmalonates. | LitMetric

Enantioenriched 1-Tetralones via Rhodium-Catalyzed Arylative Cascade Desymmetrization/Acylation of Alkynylmalonates.

Org Lett

PSL Université Paris , Chimie ParisTech-CNRS , Institute of Chemistry for Life and Health Sciences (i-CLeHS), 11 rue Pierre et Marie Curie , 75005 , Paris , France.

Published: October 2019

An efficient atom-economic rhodium-catalyzed asymmetric arylative cyclization to access enantioenriched 1-tetralones, bearing a quaternary carbon stereocenter, is described, involving a highly regioselective alkyne insertion, a 1,4-Rh shift, and an acylation step via the desymmetrization of the malonate moiety thanks to an appropriate chiral diene ligand.

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Source
http://dx.doi.org/10.1021/acs.orglett.9b03153DOI Listing

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