AI Article Synopsis
- A 42-year-old woman experienced vertigo, migraines, cognitive decline, and seizures, leading to a diagnosis of limbic encephalitis.
- Testing revealed very high levels of anti-glutamic acid decarboxylase (anti-GAD65) antibodies in both her blood and cerebrospinal fluid.
- After starting high-dose steroid treatment, her seizures stopped, cognitive functions improved to normal, and while her antibody levels decreased significantly, they remained elevated.
Article Abstract
We report the case of a 42-year-old woman who presented with vertigo and migraine and rapidly developed cognitive decline and seizures. Both serum and cerebro-spinal fluid samples showed high titer of anti-glutamic acid decarboxylase (anti-GAD65) antibodies (998,881 IU/ml and 54,687 IU/ml respectively). Limbic encephalitis was diagnosed and high dose steroids treatment started. During one-year follow-up, without further immunomodulatory therapy, the patient became seizure free, and cognitive functions returned to normal. Serum anti-GAD65 antibodies titer decreased significantly but remained elevated (192,680 IU/ml). We discuss the prognostic and pathogenic value of high titer anti-GAD65 antibodies and its variations in a case of autoimmune limbic encephalitis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jneuroim.2019.577063 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!