AI Article Synopsis
- Bullous pemphigoid (BP) is a rare blistering skin condition often treated with corticosteroids, but a 74-year-old woman showed significant improvement with omalizumab instead.
- After starting omalizumab, she experienced reduced pain and accelerated healing within a week, although she did develop mild dermatitis near the injection sites that resolved quickly.
- After 28 months, she has tolerated the treatment well without recurring skin reactions, indicating that omalizumab may be a promising option for BP, though more research is needed to understand its effects.
Article Abstract
Bullous pemphigoid (BP) is a rare blistering skin disease that is commonly treated with corticosteroids and immunosuppressive agents. Here, we present a 74-year-old woman with severe BP following a leg fracture who was successfully treated with omalizumab. We started her on a regimen of omalizumab 300 mg subcutaneously every 4 weeks, and within a week she reported significantly decreased pain and faster healing time of lesions. Incidentally, bilateral erythematous, non-blistering dermatitis developed 5 centimeters distal to the injection sites within a week of her first injection and resolved spontaneously in 2 days. She continues to tolerate the omalizumab injections well after 28 months of treatment and has not developed the injection site dermatitis since the first administration. Omalizumab appears to be a promising treatment modality for BP even when associated with transient injection site reactions, but further studies investigating the mechanisms by which omalizumab reduces bullae in BP are needed. J Drugs Dermatol. 2019;18(9):947-949.
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