The purpose of this study was to compare the effect of 24-, 36-, 48-, 72- and 96-hours between-test rest intervals on the reproducibility of the 10-RM smith machine back squat (BS), bench press (BP) and leg press at 45 degrees (LP45) exercises. Twelve resistance trained men (26.6 ± 4.5 yrs; 179.0 ± 5.5 cm; 92.2 ± 24.6 kg) performed five sets of identical 10-repetition maximum (10-RM) tests for the BS, BP, LP45 exercises, each set with a different interval between tests: 1) twenty-four hours (Post-24), 2) thirty-six hours (Post-36), 3) forty-eight hours (Post-48), 4) seventy-two (Post-72), and 5) ninety-six hours (Post-96). Significant differences in 10-RM from pretest to posttest were observed for BS in Post-24 ( < 0.001; Δ% = -12.62), Post-36 ( < 0.001; Δ% = -6.57), and Post-96 ( = 0.015; Δ% = 6.84). Similarly, significant differences in 10-RM from pretest to posttest were observed for BP in Post-24 ( < 0.001; Δ% = -9.22), Post-36 ( = 0.032; Δ% = -3.04), and Post-96 ( < 0.001; Δ% = 5.37). Finally, significant differences in 10-RM from pretest to posttest were observed for LP45 in Post-24 ( < 0.001; Δ% = -16.55), Post-36 ( = 0.032; Δ% = -5.09), and Post-96 ( < 0.001; Δ% = 5.54). The reproducibility of 10-RM was examined using intraclass correlation coefficients; BS: 0.944, 0.977, 0.988, 0.986, and 0.954 for Post-24, Post-36, Post-48, Post-72, and Post-96, respectively; BP: 0.894, 0.966, 0.966, 0.960, and 0.976; and LP45: 0.832, 0.957, 0.984, 0.974, and 0.977 5. Based on the findings, the optimal between test rest interval duration for 10-RM testing, to provide the best reproducibility, in resistance trained men appears to be 48 to 72 hours for the BS, BP, and LP45 exercises.
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http://dx.doi.org/10.70252/RYPO6126 | DOI Listing |
Cancer Chemother Pharmacol
January 2025
Markey Cancer Center, University of Kentucky, Lexington, KY, USA.
Purpose: Patients with partial or complete DPD deficiency have decreased capacity to degrade fluorouracil and are at risk of developing toxicity, which can be even life-threatening.
Case: A 43-year-old man with moderately differentiated rectal adenocarcinoma on capecitabine presented to the emergency department with complaints of nausea, vomiting, diarrhea, weakness, and lower abdominal pain for several days. Laboratory findings include grade 4 neutropenia (ANC 10) and thrombocytopenia (platelets 36,000).
Aliment Pharmacol Ther
January 2025
MASLD Research Center, Division of Gastroenterology and Hepatology, University of California at San Diego, La Jolla, California, USA.
Background: The current subclassification of steatotic liver disease (SLD) relies on validated questionnaires, such as Alcohol Use Disorders Identification Test (AUDIT) and Lifetime Drinking History (LDH), which, while useful, are impractical and lack precision for their use in routine clinical practice. Phosphatidylethanol (PEth) is a quantitative, objective alcohol biomarker with high sensitivity and specificity.
Aims: To assess the diagnostic accuracy of PEth for differentiating metabolic dysfunction and alcohol-associated liver disease (MetALD) from metabolic dysfunction-associated steatotic liver disease (MASLD) in a large, population-based, prospective, multiethnic cohort of individuals with overweight or obesity.
Eur J Med Res
January 2025
Department of Anesthesiology, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, No. 120, Longshan Road, Yubei District, Chongqing, 401147, China.
Background: Postoperative pain intensity is influenced by various factors, including genetic variations. The SCN10A gene encodes the Nav1.8 sodium channel protein, which is crucial for pain signal transmission in peripheral sensory neurons.
View Article and Find Full Text PDFCell Mol Biol Lett
January 2025
Department of Analytical Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-069, Bialystok, Poland.
The skin is a barrier that protects the human body against environmental factors (physical, including solar radiation, chemicals, and pathogens). The integrity and, consequently, the effective metabolic activity of skin cells is ensured by the cell membrane, the important structural and metabolic elements of which are phospholipids. Phospholipids are subject to continuous transformation, including enzymatic hydrolysis (with the participation of phospholipases A, C, and D) to free polyunsaturated fatty acids (PUFAs), which under the influence of cyclooxygenases (COX1/2), lipoxygenases (LOXs), and cytochrome P450 (CYPs P450) are metabolized to various classes of oxylipins, depending on the type of PUFA being metabolized and the enzyme acting.
View Article and Find Full Text PDFNat Commun
January 2025
National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, National Engineering Research Center for New Drug and Druggability (cultivation), Guangdong Province Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Epitranscriptomic modifications, particularly N6-methyladenosine (mA), are crucial regulators of gene expression, influencing processes such as RNA stability, splicing, and translation. Traditional computational methods for detecting mA from Nanopore direct RNA sequencing (DRS) data are constrained by their reliance on experimentally validated labels, often resulting in the underestimation of modification sites. Here, we introduce pum6a, an innovative attention-based framework that integrates positive and unlabeled multi-instance learning (MIL) to address the challenges of incomplete labeling and missing read-level annotations.
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