Background: The melanocortin 1 receptor (MC1R) gene is one of the major determinants of skin pigmentation. It is a highly polymorphic gene and some of its polymorphisms have been related to specific skin phenotypes, increased risk of skin cancers and skin photoageing. Currently, its contribution to changes in dermal features in photo-exposed skin is unknown.
Objective: The main objective of this study is to evaluate the potential correlation between MC1R status and specific healthy photo-exposed skin characteristics.
Materials And Methods: Skin facial features were estimated by evaluation with standard digital photography with automated features count, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) in 100 healthy women. Skin of the forearms was used as a control.
Results: The study found an association between RHC MC1R polymorphisms and dermal features in photo-exposed areas being represented by increased vessel density and pixel density in OCT (P = .025 and P = .001, respectively) and increased coarse collagen in RCM (P = .034), as compared to non-RHC subjects. To our knowledge this is previously unreported. Additionally, previously reported correlations between light hair colour and pigmented spots with MC1R RHC polymorphisms have been confirmed.
Conclusions: Our results suggest the role of RHC MC1R variants in dermal variations of facial skin, as compared to non-RHC variants. To our knowledge this is previously unreported.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/exd.14037 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Photoaging and cosmeceutical solutions in sun-overexposed countries: The experience of Australia and Brazil.
J Eur Acad Dermatol Venereol
July 2024
Department of Dermatology, Escola Paulista de Medicina - Federal University of São Paulo, São Paulo, Brazil.
Skin aging is the result of physiological changes determined by genetically driven processes and intrinsic factors, and exacerbated by a combination of multiple environmental factors, the main one being sun exposure. The effects of photoaging are particularly apparent on the face, where the appearance of aging signs can have a significant impact on the emotions conveyed and well-being. Photoprotection and facial skin care for managing photoaging signs are thus of particular importance for both physical and mental health.
View Article and Find Full Text PDFPigmented nonmelanoma skin cancers of the genital area: a diagnostic and therapeutic challenge - monocentric experience and review of the literature.
Int J Dermatol
November 2024
Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Article Synopsis
- Nonmelanoma skin cancers (NMSC), specifically basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), usually occur on sun-exposed skin but can also appear in covered areas like the genital region, where they may exhibit variable pigmentation.
- Accurate diagnosis is crucial due to the risk of mucosal melanoma, and this review discusses the diagnosis and management of pigmented NMSC (pNMSC) in the genital area, highlighting the importance of dermoscopy and reflectance confocal microscopy in assessment.
- Pigmented variants of BCC and SCC are rare, with specific dermoscopic features noted for diagnosis, and it is essential to differentiate pNMSC from benign lesions and melanoma to ensure appropriate treatment.
Actinic conjunctivitis and its relationship with prurigo in an indigenous population from the Highlands of Chiapas, Mexico.
Int Ophthalmol
February 2024
Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico.
Article Synopsis
- This study investigates actinic conjunctivitis (AC) and its connection to actinic prurigo (AP) in Indigenous populations from Chiapas, Mexico, focusing on clinical manifestations and onset.* ! -
- Out of 2913 patients, only 54 (1.8%) were diagnosed with AC, predominantly affecting individuals around 36 years old, with the majority experiencing significant sun exposure and environmental factors like cooking with biomass fuels.* ! -
- Findings indicate that AC can manifest as the sole symptom of AP and often presents at advanced stages, with a notable link to exposure to farm animals, and previously unreported cases of evaporation dry eye disease associated with AC.* !
Porokeratotic Variant of Lichen Planus.
Skinmed
November 2022
Department of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
A 44-year-old woman presented with mildly itchy, brownish-black plaques for the last 2 years. The lesions first appeared on the upper back, followed by involvement of the face and upper arms within 4-5 months. Individual lesions began as small papules that gradually evolved into small, annular, and barely palpable plaques.
View Article and Find Full Text PDFReflectance Confocal Microscopy of Pigmented Bowen's Disease: A Case Series of Difficult to Diagnose Lesions.
Case Rep Dermatol
May 2020
Department of Medicine and Medical Specialties, University of Alcalá, Madrid, Spain.
Pigmented Bowen's disease is a rare variant of in situ squamous skin cell carcinoma. It mainly affects patients between 60 and 70 years of age. Its clinical features include well-demarcated, pigmented plaque arising in photo-exposed areas of the body.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!