AI Article Synopsis

  • The study focuses on γ-Glutamylcyclotransferase (GGCT), a protein found in high levels in various cancers, and its potential as a target for therapy.
  • Researchers explored if blocking GGCT would enhance the effectiveness of docetaxel, a drug used in prostate cancer treatment.
  • Results showed that GGCT inhibition reduced cancer cell growth and, when combined with docetaxel, produced stronger anti-cancer effects than either treatment alone.

Article Abstract

Background/aim: γ-Glutamylcyclotransferase (GGCT) is highly expressed in many forms of cancer, and is a promising therapeutic target. The present study investigated whether inhibition of GGCT enhanced the antiproliferative effects of the drug docetaxel in prostate cancer cells.

Materials And Methods: Immunohistochemistry and western blot analysis were conducted to measure GGCT expression in prostate cancer tissue samples and cell lines. GGCT was inhibited using RNAi and a novel enzymatic inhibitor, pro-GA, and cell proliferation was evaluated with single and combination treatments of GGCT inhibitors and docetaxel.

Results: GGCT was highly expressed in cultured prostate cancer cells and patient samples. GGCT inhibition alone inhibited prostate cancer cell line proliferation and induced cellular senescence. GGCT inhibition in combination with apoptosis-inducing docetaxel had more potent antiproliferative effects than either drug used alone.

Conclusion: GGCT inhibition may potentiate anticancer drug efficacy.

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Source
http://dx.doi.org/10.21873/anticanres.13666DOI Listing

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