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Cutaneous infection in a patient with metastatic renal cell carcinoma.
JAAD Case Rep
October 2024
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.
Simultaneous distinct cutaneous fungal infections with chromoblastomycosis due to Exophiala xenobiotica and hyalohyphomycosis due to Scedosporium apiospermum in a patient with severe cellular immunodeficiency.
J Dermatol
December 2024
Department of Dermatology, Kawasaki Medical School, Kurashiki, Japan.
Article Synopsis
- Deep-seated dermatomycosis is a rare fungal infection often linked to trauma and a weakened immune system, as seen in a 92-year-old Japanese man with a respiratory condition.
- The patient developed distinct skin lesions and several abscesses caused by two different fungi, Exophiala xenobiotica and Scedosporium apiospermum, with severe cellular immunodeficiency indicated by low immune response tests.
- Despite antifungal treatment, he ultimately died from bacterial pneumonia, highlighting how corticosteroids can impair immune function and worsen fungal infections.
A rare case of scedosporium apiospermum osteomyelitis in an immunocompetent patient.
IDCases
January 2024
Mayo Clinic Florida, Infectious Disease Department, United States.
Scedosporium, a widespread filamentous fungus found in diverse environments, has experienced a rise in cases due to escalating malignancies and chronic immunosuppression. Clinical manifestations span mycetoma, airway involvement, and various infections, with osteomyelitis being a notable complication. We present a case of a 77-year-old female initially displaying cutaneous Scedosporium signs, which progressed to osteomyelitis.
View Article and Find Full Text PDFCutaneous Hyalohyphomycosis and Its Atypical Clinical Presentations in Immunosuppressed Patients.
Life (Basel)
January 2024
Clinical Department of Pathology and Cytology, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, Croatia.
There has been a substantial increase in the number of cases of invasive fungal infections worldwide, which is associated with a growing number of immunosuppressed patients and a rise in antifungal resistance. Some fungi that were previously considered harmless to humans have become emerging pathogens. One of them is , a ubiquitous filamentous fungus commonly found in the environment, especially in the air and soil.
View Article and Find Full Text PDFDevelopment of a monoclonal antibody and a lateral-flow device for the rapid detection of a Mucorales-specific biomarker.
Front Cell Infect Microbiol
December 2023
Biosciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
Article Synopsis
- Current diagnosis methods are slow and non-specific, lacking rapid tests for identifying specific Mucorales infections.
- A new IgG2b monoclonal antibody (TG11) has been developed that detects specific polysaccharide antigens, enabling a quick 30-minute test for mucoromycosis in human serum and bronchoalveolar lavage samples.
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