Temporal dissipative Kerr solitons (DKSs) in microresonators provide ultra-short optical pulses and low-noise frequency combs with gigahertz to terahertz repetition rates. Owing to their unique properties, they have found application in fields, including optical communications, rapid laser ranging, and optical precision spectroscopy. However, due to the thermal instability encountered when entering the DKS regime, the stable generation of solitons remains challenging for many systems and usually requires rapid actuation of the pump laser detuning, pulsed driving, additional lasers, a particular mode structure and/or active feedback loops to stabilize the system. Here we show that slow pump modulation can remove the thermal instability and enable passively stable soliton states that can be readily accessed via arbitrarily slow laser tuning, thereby greatly reducing the technical complexity of stable DKS generation.
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http://dx.doi.org/10.1364/OL.44.004447 | DOI Listing |
HardwareX
June 2024
Institute for Medical Bioinformatics and Biostatistics (IMBB), Philipps University of Marburg, Hans-Meerwein-Strasse 6, 35032 Marburg, Germany.
The advent of single cell technologies resulted in growing demand for microfluidics in the biological sciences. Commercial platforms have remained expensive, inflexible, and non-customizable black boxes. We developed an open source, multichannel, zero-backflow microfluidics device based on syringe pumps controlled by a Raspberry Pi computer.
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Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
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January 2025
Department of Anatomy & Neuroscience, School of Medicine, University College Cork (UCC), Cork, Ireland; APC Microbiome Ireland, UCC, Cork, Ireland. Electronic address:
Degeneration of midbrain nigrostriatal dopaminergic neurons is a pathological hallmark of Parkinson's disease (PD). Peripheral delivery of a compound(s) to arrest or slow this dopaminergic degeneration is a key therapeutic goal. Pan-inhibitors of histone deacetylase (HDAC) enzymes, key epigenetic regulators, have shown therapeutic promise in PD models.
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Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
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View Article and Find Full Text PDFDevice
October 2024
Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Naloxone can effectively rescue victims from opioid overdose, but less than 5% survive due to delayed or absent first responder intervention. Current overdose reversal systems face key limitations, including low user adherence, false positive detection, and slow antidote delivery. Here, we describe a subcutaneously implanted robotic first responder to overcome these challenges.
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