Dysregulation of N-methyladenosine regulators predicts poor patient survival in mantle cell lymphoma.

N-methyladenosine (mA) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are known to serve crucial roles in mRNA metabolism. However, the role of mA during B-cell development and B-cell tumorigenesis remains poorly understood. By analyzing the gene expression profile of 123 mantle cell lymphoma cases from the Gene Expression Omnibus database, the present study demonstrated that one-half of the mA regulators were able to predict patient survival in mantle cell lymphoma, notably the mA.index. The expression levels of the mA regulators were regarded as good classifiers in mantle cell lymphoma. The mA.index-low mantle cell lymphoma type exhibited a poor patient survival and lower mRNA levels from the total transcriptome. The mA regulators may be associated with the cell division and the RNA metabolic pathways, which may result in poor survival of patients with mantle cell lymphoma.