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[Effects of platelet-derived growth factor on nerve regeneration around implant in rats]. | LitMetric
Objective : To investigate the effect of platelet-derived growth factor (PDGF) on nerve regeneration in peri-implant tissues.Methods : SD rats with implants in their femurs were injected with PDGF solution. The effects of PDGF on nerve regeneration in peri-implant tissues were analyzed by immunohistochemical staining.Results : PDGF increased the number of nerve fibers in peri-implant tissues at early stage. PDGF had no significant effect on the number of nerve fibers in peri-implant tissues at late stage. Moreover, these nerves had a typical structure of peripheral nerve fibers.Conclusions : PDGF can promote nerve regeneration in peri-implant tissues at early stage. This study provided a certain experimental basis for the clinical application of PDGF to promote nerve regeneration and further improve the sensory function of the implant.
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