Study of mastoparan analog peptides against and safety in zebrafish embryos ().

In this work, mastoparan analog peptides from wasp venom were tested against and safety assays were performed using cell culture and model zebrafish. Minimal inhibitory concentration was determined and toxicity was performed using human skin keratinocyte and embryo zebrafish. Also, permeation of peptides through embryo chorion was performed. The peptides demonstrated anti- activity, with low cytotoxicity and nonteratogenicity in . The compounds had different permeation through chorion, suggesting that this occurs due to modifications in their amino acid sequence. The results showed that the studied peptides can be used as structural study models for novel potential antifungal agents.