A simplified phase-stable dual-comb interferometer for absolute distance measurement within a short dynamic range is proposed in this paper. The experimental results demonstrate that stable phase-difference information and lower timing jitter can be obtained within a time delay of 2000 ns between the reference interference signal and measurement interference signal. Using the proposed technique, the time-of-flight (TOF) result can link directly to the carrier-wave interferometric (CWI) result in an average time of 20 ms and can reach 2 nm precision in 0.5 s averaging time. Millimeter-scale measurement dynamic range and nanometer-level precision can thus be achieved without additional noise suppression. This method can also be applied at different stand-off distances.
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http://dx.doi.org/10.1364/OE.27.022868 | DOI Listing |
Pain is a dynamic and nonlinear experience shaped by injury and contextual factors, including expectations of future pain or relief . While µ opioid receptors are central to the analgesic effects of opioid drugs, the endogenous opioid neurocircuitry underlying pain and placebo analgesia remains poorly understood. The ventrolateral column of the posterior periaqueductal gray is a critical hub for nociception and endogenous analgesia mediated by opioid signaling .
View Article and Find Full Text PDFCancer cells within tumors exhibit a wide range of phenotypic states driven by non-genetic mechanisms in addition to extensively studied genetic alterations. Conversions among cancer cell states can result in intratumoral heterogeneity which contributes to metastasis and development of drug resistance. However, mechanisms underlying the initiation and/or maintenance of such phenotypic plasticity are poorly understood.
View Article and Find Full Text PDFbioRxiv
December 2024
Rutherford Appleton Laboratory, Research Complex at Harwell, Didcot, Oxfordshire, UK.
Conjugation, the major driver of the spread of antimicrobial resistance genes, relies on a conjugation pilus for DNA transfer. Conjugative pili, such as the F-pilus, are dynamic tubular structures, composed of a polymerized pilin, that mediate the initial donor-recipient interactions, a process known as mating pair formation (MPF). IncH are low-copy-number plasmids, traditionally considered broad host range, which are found in bacteria infecting both humans and animals.
View Article and Find Full Text PDFEcol Evol
January 2025
Dynamic Macroecology/Land Change Science Swiss Federal Institute for Forest, Snow and Landscape Research WSL Birmensdorf Switzerland.
High-Arctic environments are facing an elevated pace of warming and increasing human activities, making them more susceptible to the introduction and spread of alien species. We investigated the role of human disturbance in facilitating the spread of a native plant () in a high-Arctic natural environment close to Isfjord Radio station and along adjacent hiking trails at Kapp Linné, Svalbard. We reconstructed the spatial pattern of the arrival and spread of at Kapp Linné by combining historical records of the species occurrence (1928-2018) with a contemporary survey of the plant abundance along the main hiking trail (2023 survey) and tested the relative effects of altitude and proximity to hiking trails on the species density via a generalised linear model (GLM).
View Article and Find Full Text PDFEcol Evol
January 2025
United States Fish and Wildlife Service, Texas Fish and Wildlife Conservation Office San Marcos Texas USA.
Karst ecosystems often contain extraordinary biodiversity, but the complex underground aquifers of karst regions present challenges for assessing and conserving stygobiont diversity and investigating their evolutionary history. We examined the karst-obligate salamanders of the species complex in the Edwards Plateau region of central Texas using population genomics data to address questions about population connectivity and the potential for gene exchange within the underlying aquifer system. The species complex has historically been divided into three nominal species, but their status, and spatial extent of species ranges, have remained uncertain.
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