Photonic ring resonators can be considered building blocks of new concept satellite payloads for implementing several functions, such as filtering and sensing. In particular, the use of a high Q-factor ring resonator as sensing element into a Resonant Micro Optic Gyroscope (RMOG), provides a remarkable improvement of the performance with respect to the competitive technologies. To qualify a ring resonator for Space applications, the radiation effects on it in the Space must be carefully evaluated. Here, we investigate the effects of gamma radiation on a high Q InGaAsP/InP ring resonator, for the first time, to our knowledge. The ring resonator under study has a footprint of about 530 mm and it is based on a InGaAsP/InP rib waveguide, with a width of 2 µm and a thickness of 0.3 µm, formed on a 0.7 µm thick slab layer on an InP substrate 625 µm thick. For a total dose of about 320 krad Co60 gamma irradiation, a mean variation of about 13% and 4% was measured for Q and extinction ratio (ER), respectively, with respect to the values before irradiation (Q = 1.36 × 10, ER = 6.24 dB). Furthermore, the resonance peak red-shifts with a linear behaviour was observed increasing the total dose of the absorbed radiation, with a maximum resonance detuning of about 810 pm. These non-significant effects of a quite high gamma radiation dose confirm the potential of high-Q InP-based ring resonators into Space systems or subsystems.
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http://dx.doi.org/10.1364/OE.27.024434 | DOI Listing |
J Org Chem
January 2025
Faculty of Chemistry and Center for Molecular Materials (CM2), Bielefeld University, Universitätsstraße 25, Bielefeld 33615, Germany.
Spin labels based on Gd complexes are important tools for the elucidation of the structure, dynamics and interaction of biomolecules by electron paramagnetic resonance (EPR) spectroscopy. Their EPR spectroscopic properties line width and relaxation times influence their performance in a particular application. To be able to apply a complex well-suited for a specific application, a set of Gd complexes with different EPR spectroscopic properties ready-made for spin labeling will be highly useful.
View Article and Find Full Text PDFJ Org Chem
January 2025
School of Medicine, Shanghai University, 99 Shangda Road, BaoShan District, Shanghai 200444, China.
Uncommon diterpenoids with diverse frameworks, including one unexpected iodinated oxa-6/6/6/6-tetracyclic diterpene () and its monobrominated 6/6/6-tricyclic analogue () and one novel isodolastane-type diterpene featuring an unusual aromatic 5/7/6-tricyclic ring system () as well as a related known dolastane-type diterpenoid (), were isolated from the South China Sea sponge . Their structures, including absolute configurations, were established by extensive spectroscopic data analysis, X-ray diffraction analysis, and quantum mechanical-nuclear magnetic resonance and time-dependent density functional theory/electronic circular dichroism calculations. A plausible biosynthetic pathway of new compounds - was proposed.
View Article and Find Full Text PDFNMC Case Rep J
December 2024
Department of Neurosurgery, Institute of Science Tokyo, Tokyo, Japan.
Moyamoya disease (MMD) is characterized by distinct histopathological changes in intracranial arteries, such as narrowing of the arterial lumen due to thickening of the tunica intima, waving of the internal elastic membranes, and thinning of the tunica media. Ring finger protein 213 is a susceptibility gene for MMD that affects clinical outcomes. However, little is known about its relationship with histopathology.
View Article and Find Full Text PDFNMR Biomed
March 2025
Department of Radiology, Clínica Universidad de Navarra, Pamplona, Spain.
Hemodynamic measurements such as cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) can provide useful information for the diagnosis and characterization of brain tumors. Previous work showed that arterial spin labeling (ASL) in combination with vasoactive stimulation enabled simultaneous non-invasive evaluation of both parameters, however this approach had not been previously tested in tumors. The aim of this work was to investigate the application of this technique, using a pseudo-continuous ASL (PCASL) sequence combined with breath-holding at 3 T, to measure CBF and CVR in high-grade gliomas and metastatic lesions, and to explore differences across tumoral-peritumoral regions and tumor types.
View Article and Find Full Text PDFJ Clin Neurosci
January 2025
Department of Neurological Surgery and Rosa Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. Electronic address:
Background And Objective: Radiosurgery can serve as a primary, adjuvant, or salvage treatment modality for cavernous sinus tumors (CST), providing high tumor control. However, particularly with cavernous sinus expansion, there may be insufficient distance from the optic apparatus to perform radiosurgery safely. The internal carotid artery adjacent to the distal dural ring (ICAddr), when enhancing similarly to the CST, can be difficult to delineate, and can lead to over-contouring of target volume near the optic nerve and therefore increasing the risk of radiation-induced optic toxicity.
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