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The association of PM with airway innate antimicrobial activities of salivary agglutinin and surfactant protein D. | LitMetric

The association of PM with airway innate antimicrobial activities of salivary agglutinin and surfactant protein D.

Chemosphere

Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou, 515041, Guangdong, China; Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, Guangdong, China. Electronic address:

Published: July 2019

AI Article Synopsis

Article Abstract

Fine particulate matter ≤2.5 μm (PM) is a prominent global public health risk factor that can cause respiratory infection by downregulating the amounts of antimicrobial proteins and peptides (AMPs). Both salivary agglutinin (SAG) and surfactant protein D (SPD) are important AMPs in respiratory mucosal fluid, providing protection against airway pathogen invasion and infection by inducing microbial aggregation and enhancing pathogen clearance. However, the relationship between PM and these AMPs is unclear. To better understand the relationship between PM and airway innate immune defenses, we review the respiratory antimicrobial activities of SAG and SPD, as well as the adverse effects of PM on airway innate antimicrobial defense. We speculate there exists a dual effect between PM and respiratory antimicrobial activity, which means that PM suppresses respiratory antimicrobial activity through downregulating airway AMPs, while airway AMPs accelerate PM clearance by inducing PM microbial aggregation. We propose further research on the relationship between PM and these AMPs.

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Source
http://dx.doi.org/10.1016/j.chemosphere.2019.04.032DOI Listing

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