AI Article Synopsis
- The emergence of drug-resistant Candida strains highlights the urgent need for new antifungal alternatives.
- Silver nanoparticles, created through a green synthesis method, show effectiveness in inhibiting growth of both C. albicans and C. glabrata, including fluconazole-resistant strains.
- The study also found that these nanoparticles significantly prevent biofilm formation, suggesting that they could serve as promising phytotherapeutic treatments for oral candidiasis.
Article Abstract
The continuous emergence of Candida strains resistant to currently used antifungals demands the development of new alternatives that could reduce the burden of candidiasis. In this work silver nanoparticles synthesized using a green route are efficiently used, alone or in combination with fluconazole, amphotericin B or nystatine, to inhibit growth of C. albicans and C. glabrata oral clinical strains, including in strains showing resistance to fluconazole. A potent inhibitory effect over biofilm formation prompted by the two Candida species was also observed, including in mature biofilm cells. These results foster the use of phytotherapeutics as effective treatments in oral candidiasis.
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| http://dx.doi.org/10.1093/mmy/myz094 | DOI Listing |
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