The study analyzed the life and healthcare stories of women living in the Northwest Zone of the city of Santos, São Paulo State, Brazil, who had experienced neonatal deaths between January 2015 and July 2016. The study used triangulation of data from documents from the surveillance division, field diaries from visits to services, and interviews with the women. The interviews provided the main body of empirical data, based on narratives of the women's sexual and reproductive history, prenatal care, childbirth, and the experience of neonatal death. Of the 15 eligible cases, 8 women were interviewed, 6 of whom over 30 years of age and 2 under 30 years, all African-Brazilians, natives of Santos, and working in unskilled occupations. The data yielded the following results: (1) histories of unplanned pregnancies with various gestational risk factors; (2) the women's acknowledgment that they had experienced good access to health services; (3) questions concerning the need for tests and test results, understanding of complications, explanation of treatment approaches, and referrals; (4) prematurity, present in all the cases; (5) pain during labor, abandonment, and transfer to other services due to lack of beds in the neonatal ICU; (6) lack of integration between levels of care; and (7) after the infant's death, limited approaches and little orientation on comprehensive care related to the neonatal death. In conclusion, although the prenatal care was positively rated by the women, there was no comprehensive care for them in relation to the experience of neonatal death, with dialogue and an offer of more adequate contraceptive methods given their health history, as well as counseling on the emotional distress resulting from these experiences.
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http://dx.doi.org/10.1590/0102-311X00081718 | DOI Listing |
Virol J
December 2024
Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
PEDV is a highly contagious enteric pathogen that can cause severe diarrhea and death in neonatal pigs. Despite extensive research, the molecular mechanisms of host's response to PEDV infection remain unclear. In this study, differentially expressed genes (DEGs), time-specific coexpression modules, and key regulatory genes associated with PEDV infection were identified.
View Article and Find Full Text PDFArch Dis Child Fetal Neonatal Ed
December 2024
Nuffield Department of Population Health, University of Oxford National Perinatal Epidemiology Unit, Oxford, UK.
Objective: Babies born between 27 and 31 weeks of gestation contribute substantially towards infant mortality and morbidity. In England, their care is delivered in maternity services colocated with highly specialised neonatal intensive care units (NICU) or less specialised local neonatal units (LNU). We investigated whether birth setting offered survival and/or morbidity advantages to inform National Health Service delivery.
View Article and Find Full Text PDFArch Dis Child Fetal Neonatal Ed
December 2024
Centre for Research in Epidemiology and Statistics Obstetrical Perinatal and Pediatric Epidemiology Research Team, Paris, Île-de-France, France.
Objective: The objective is to evaluate changes in survival to discharge of liveborn infants less than 32 weeks' gestational age (GA) in France, where the latest available data on very preterm survival at a national-level are from the EPIPAGE-2 cohort in 2011.
Design: Population-based cohort study.
Setting: Metropolitan France in 2011, 2015 and 2020.
Metabolites
December 2024
Division of Metabolic and Cardiovascular Sciences, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.
Cardiac diseases remain one of the leading causes of death globally, often linked to ischemic conditions that can affect cellular homeostasis and metabolism, which can lead to the development of cardiovascular dysfunction. Considering the effect of ischemic cardiomyopathy on the global population, it is vital to understand the impact of ischemia on cardiac cells and how ischemic conditions change different cellular functions through post-translational modification of cellular proteins. : To understand the cellular function and fine-tuning during stress, we established an ischemia model using neonatal rat ventricular cardiomyocytes.
View Article and Find Full Text PDFInt J Neonatal Screen
December 2024
Laboratory of Genomic, Epigenetics, Precision and Predictive Medicine, School of Medicine, Mohammed VI University of Sciences and Health, Casablanca 82403, Morocco.
Unlabelled: Newborn screening (NBS) represents an important public health measure for the early detection of specified disorders; such screening can prevent disability and death, not only from metabolic disorders but also from endocrine, hematologic, immune, and cardiac disorders. Screening for critical congenital conditions affecting newborns' health is a great challenge, especially in developing countries such as Morocco, where NBS program infrastructure is lacking. In addition, the consanguinity rate is high in Morocco.
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