AI Article Synopsis
- Diabetes affects gene expression of specific integrin subunits in various tissues, including the endometrium, and may impact pregnancy success.
- The study analyzed endometrial gene expression of integrin subunits in diabetic rat models during embryo implantation, using real-time PCR.
- Results showed increased expression of these subunits in diabetic rats, with pioglitazone reducing expression levels, while metformin elevated certain subunits, suggesting untreated diabetes may contribute to embryo implantation failure.
Article Abstract
Background: Diabetes mellitus deeply changes the genes expression of integrin () subunits in several cells and tissues such as monocytes, arterial endothelium, kidney glomerular cells, retina. Furthermore, hyperglycemia could impress and reduce the rate of successful assisted as well as non-assisted pregnancy. Endometrium undergoes thorough changes in normal menstrual cycle and the question is: What happens in the endometrium under diabetic condition?
Objective: The aim of the current study was to investigate the endometrial gene expression of α3, α4, αv, β1 and β3 subunits in diabetic rat models at the time of embryo implantation.
Materials And Methods: Twenty-eight rats were randomly divided into 4 groups: control group, diabetic group, pioglitazone-treated group, and metformin-treated group. Real-time PCR was performed to determine changes in the expression of α3, α4, αv, β1, and β3 genes in rat's endometrium.
Results: The expression of all subunits increased significantly in diabetic rats' endometrium compared with control group. Treatment with pioglitazone significantly reduced the level of subunits gene expression compared with diabetic rats. While metformin had a different effect on α3 and α4 and elevated these two subunits gene expression.
Conclusion: Diabetes mellitus significantly increased the expression of studied subunits, therefore untreated diabetes could be potentially assumed as one of the preliminary elements in embryo implantation failure.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719519 | PMC |
| http://dx.doi.org/10.18502/ijrm.v17i6.4810 | DOI Listing |
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