AI Article Synopsis
- The study investigated the anticancer effects of sweet cherry extract on human prostate cells, focusing on different cherry cultivars from Fundão, Portugal.
- The Saco "late harvest" extract, rich in anthocyanins, was used in biological assays on both non-neoplastic (PNT1A) and neoplastic (LNCaP and PC3) prostate cells.
- Results showed that the cherry extract reduced cell viability in both types of cells, increased apoptosis particularly in LNCaP cells, and decreased oxidative damage and glycolytic metabolism in the neoplastic cells.
Article Abstract
The present work evaluated the anticancer properties of sweet cherry () extract on human prostate cells. Several sweet cherry cultivars from Fundão (Portugal) were methanol-extracted and their phytochemical composition characterized. The Saco "late harvest" extract was highly-enriched in anthocyanins and selected for use in biological assays. Non-neoplastic (PNT1A) and neoplastic (LNCaP and PC3) human prostate cells were treated with 0-2,000 μg/ml of extract for 48-96 h. Cell viability was evaluated by the MTT assay. Apoptosis, oxidative stress, and glycolytic metabolism were assessed by Western blotting and enzymatic assays. Glucose consumption and lactate production were measured spectrophotometrically. Saco cherry extract diminished the viability of neoplastic and non-neoplastic cells, whereas enhancing apoptosis in LNCaP. Cherry extract-treatment also diminished oxidative damage and suppressed glycolytic metabolism in LNCaP cells. These findings widened the knowledge on the mechanisms by which cherry extract modulate cell physiology, demonstrating their broad action over the hallmarks of cancer.
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| http://dx.doi.org/10.1080/01635581.2019.1661502 | DOI Listing |
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