We report a new application of -amino-7-azaindole as a new bidentate-directing group for [Ru(-cymene)Cl]-catalyzed C(sp)-H alkenylation/annulation of -(1-pyrrolo[2,3-]pyridin-1-yl)benzamides with internal alkynes to afford -isoquinolono-7-azaindole via the formation of C-C and C-N bonds. The reaction shows a wide range of substrate scope with different symmetrical and unsymmetrical alkynes, affording the desired product in good to excellent yields. In the case of unsymmetrical alkynes, a highly regioselective product was obtained, which was confirmed by single-crystal X-ray crystallography. A new ruthenium-4-methyl--(1-pyrrolo[2,3-]pyridin-1-yl)benzamide complex was isolated, and its structure was confirmed by single-crystal X-ray crystallography.
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