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| http://dx.doi.org/10.2105/AJPH.2019.305151 | DOI Listing |
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Deciphering Consciousness: The Role of Corticothalamocortical Interactions in General Anesthesia.
Pharmacol Res
January 2025
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, China. Electronic address:
General anesthesia is administered to millions of individuals each year, however, the precise mechanism by which it induces unconsciousness remains unclear. While some theories suggest that anesthesia shares similarities with natural sleep, targeting sleep-promoting areas and inhibiting arousal nuclei, recent research indicates a more complex process. Emerging evidence highlights the critical role of corticothalamocortical circuits, which are involved in higher cognitive functions, in controlling arousal states and modulating transitions between different conscious states during anesthesia.
View Article and Find Full Text PDFGetting the numbers right: Power, creativity and 'good' routine maternal and neonatal health data in Southern Tanzania.
Soc Sci Med
January 2025
Institute of Tropical Medicine Antwerp, Sint-Rochusstraat 43, 2000, Antwerp, Belgium.
What makes routine maternal and neonatal health data to be 'good quality'? That depends on whom you ask - the people collecting and reporting these data across health system levels have different priorities and face varying constraints. Data are constructed by people, about people, and they both reflect and impact human interactions. This study analyses the power dynamics shaping how routine health data are collected and reported in labour wards of two hospitals in Southern Tanzania.
View Article and Find Full Text PDFTop-Down versus Bottom-Up Approaches for σ-Functionals Based on the Approximate Exchange Kernel.
J Phys Chem A
January 2025
Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, D-81377 Munich, Germany.
Recently, we investigated a number of so-called σ- and τ-functionals based on the adiabatic-connection fluctuation-dissipation theorem (ACFDT); particularly, extensions of the random phase approximation (RPA) with inclusion of an exchange kernel in the form of an antisymmetrized Hartree kernel. One of these functionals, based upon the approximate exchange kernel (AXK) of Bates and Furche, leads to a nonlinear contribution of the spline function used within σ-functionals, which we previously avoided through the introduction of a simplified "top-down" approach in which the σ-functional modification is inserted a posteriori following the analytic coupling strength integration within the framework of the ACFDT and which was shown to provide excellent performance for the GMTKN55 database when using hybrid PBE0 reference orbitals. In this work, we examine the analytic "bottom-up" approach in which the spline function is inserted a priori, i.
View Article and Find Full Text PDFA Neural-Network-Based Mapping and Optimization Framework for High-Precision Coarse-Grained Simulation.
J Chem Theory Comput
January 2025
Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
The accuracy and efficiency of a coarse-grained (CG) force field are pivotal for high-precision molecular simulations of large systems with complex molecules. We present an automated mapping and optimization framework for molecular simulation (AMOFMS), which is designed to streamline and improve the force field optimization process. It features a neural-network-based mapping function, DSGPM-TP (deep supervised graph partitioning model with type prediction).
View Article and Find Full Text PDFToward Hyphenated Infrared and Raman Spectroscopies in Interfacial Electrochemistry.
Anal Chem
January 2025
Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemistry, Fudan University, Shanghai 200438, China.
To address the pressing demand for hyphenated characterization of the electrode-electrolyte interfaces at the molecular level, we report herein a technical note to demonstrate the hyphenation of electrochemical surface-enhanced infrared absorption spectroscopy (SEIRAS) and shell-isolated nanoparticle enhanced Raman spectroscopy (SHINERS). The core setup incorporates a top-down configured Raman optic fiber head loaded on a 3-dimension positioning module and a bottom-up configured attenuated total reflection infrared spectroscopy (ATR-IR) spectroelectrochemical cell accommodated in a custom-designed optical accessory. The feasibility of this integrated design is initially validated by the simultaneous measurement of two model systems, namely, potential dependent adsorption of pyridine on a Au film electrode and the CO reduction reaction on a Cu film electrode by SEIRAS and SHINERS, yielding distinct and complementary spectral information.
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