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| http://dx.doi.org/10.1093/jac/dkz372 | DOI Listing |
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High-Throughput Shotgun Metagenomics of Microbial Footprints Uncovers a Cocktail of Noxious Antibiotic Resistance Genes in the Winam Gulf of Lake Victoria, Kenya.
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Department of Biological Sciences, School of Natural and Applied Sciences, Masinde Muliro University of Science and Technology, P.O. Box 190, Kakamega 50100, Kenya.
A diverse range of pollutants, including heavy metals, agrochemicals, pharmaceutical residues, illicit drugs, personal care products, and other anthropogenic contaminants, pose a significant threat to aquatic ecosystems. The Winam Gulf of Lake Victoria, heavily impacted by surrounding human activities, faces potential contamination from these pollutants. However, studies exploring the presence of antibiotic resistance genes (ARGs) in the lake remain limited.
View Article and Find Full Text PDFCharting the global footprint of borderline oxacillin-resistant (BORSA): the first systematic review and meta-analysis.
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Department of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Borderline oxacillin-resistant (BORSA) has been a persistent yet under-researched concern in the realm of antibiotic resistance, characterized by unique resistance mechanisms and potential for severe infections. This systematic review and meta-analysis consolidates data from 29 studies encompassing 18,781 samples, revealing a global BORSA prevalence of 6.6% (95% CI [4.
View Article and Find Full Text PDFHarnessing the Power of Zinc Oxide Nanoparticles for Accelerated Wound Healing and Antimicrobial Action.
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School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, Karnataka, India.
Introduction: Zinc oxide nanoparticles (ZnONPs) have been the subject of substantial research by virtue of their utility across extensive downstream applications. Moreover, the ZnONPs are inexpensive, reliable, and easy to produce. Green synthesis employing biological systems, particularly plant extracts, has arisen as a subject of study in nanotechnology and is gaining importance due to its multiple applications in biology, chemistry, physics, and medicine.
View Article and Find Full Text PDFBioluminescent Whole-Cell Bioreporter Bacterial Panel for Sustainable Screening and Discovery of Bioactive Compounds Derived from Mushrooms.
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Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Faculty of Engineering Sciences, Ben-Gurion University of Negev, Beer Sheva 84105, Israel.
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- This study introduces a fast and thorough method to screen mushroom extracts for potential bioactive molecules, especially those with antimicrobial properties.
- The method uses bioluminescent bacteria that emit light to indicate various harmful effects caused by the mushroom extracts, such as disrupting bacterial communication and damaging proteins and DNA.
- The approach allows for the simultaneous analysis of many samples and mechanisms of toxicity, significantly speeding up the screening process and revealing the diverse antibacterial effects of the mushroom extracts.
Povidone-iodine and silver nitrate are equally effective in eradicating staphylococcal biofilm grown on a titanium surface: an in-vitro analysis.
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'Sir John Charnley' Hip Surgery Unit, Institute of Orthopaedics 'Carlos E. Ottolenghi', Italian Hospital of Buenos Aires, Buenos Aires, Argentina. Electronic address:
Article Synopsis
- The study investigates which antibacterial solutions are most effective in eradicating biofilms formed by staphylococcal bacteria on titanium surfaces during DAIR surgery.
- Five antibacterial agents are tested: povidone-iodine, rifampicin, silver nitrate, copper sulphate, and chlorhexidine, focusing on their minimum biofilm eradication concentrations (MBEC) against both MSSA and MRSA strains.
- Results indicate that povidone-iodine and silver nitrate are significantly more effective, achieving at least 99.9% reduction in biofilm, compared to others like rifampicin and copper sulphate, which showed limited effectiveness.
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