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| http://dx.doi.org/10.1093/gbe/evz169 | DOI Listing |
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A Rare Case of Fatal Toxic Epidermal Necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome in a Patient with Rheumatoid Arthritis.
Curr Drug Saf
January 2025
Topiwala National Medical College & BYL Nair Charitable Hospital, Clinical Pharmacology, India.
Introduction: This case study presents a rare and fatal instance of Toxic Epidermal Necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome in a 51-year-old male patient diagnosed with Rheumatoid Arthritis (RA).
Case Presentation: The patient was initially treated with sulfasalazine, leflunomide, and hydroxychloroquine, following which he developed a rash, fever, and loose stools. Drug allergy was suspected, and the antirheumatic medications were withdrawn, following which, the patient improved.
This study presents an integrated framework that combines spatial clustering techniques and multi-source geospatial data to comprehensively assess and understand geological hazards in Hunan Province, China. The research integrates self-organizing map (SOM) and geo-self-organizing map (Geo-SOM) to explore the relationships between environmental factors and the occurrence of various geological hazards, including landslides, slope failures, collapses, ground subsidence, and debris flows. The key findings reveal that annual average precipitation (Pre), profile curvature (Pro_cur), and slope (Slo) are the primary factors influencing the composite geological hazard index (GI) across the province.
View Article and Find Full Text PDFNonlinear exposure-response associations of daytime, nighttime, and day-night compound heatwaves with mortality amid climate change.
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School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China.
Heatwaves are commonly simplified as binary variables in epidemiological studies, limiting the understanding of heatwave-mortality associations. Here we conduct a multi-country study across 28 East Asian cities that employed the Cumulative Excess Heatwave Index (CEHWI), which represents excess heat accumulation during heatwaves, to explore the potentially nonlinear associations of daytime-only, nighttime-only, and day-night compound heatwaves with mortality from 1981 to 2010. Populations exhibited high adaptability to daytime-only and nighttime-only heatwaves, with non-accidental mortality risks increasing only at higher CEHWI levels (75th-90th percentiles).
View Article and Find Full Text PDFInorganic substrates in frozen solutions: Transformation mechanisms and interactions with organic compounds - A review.
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Advanced Interdisciplinary Institute of Environment and Ecology, Guangdong Provincial Key Laboratory of Wastewater Information Analysis and Early Warning, Beijing Normal University, Zhuhai 519087, China. Electronic address:
In cold environments, such as polar regions and high latitudes, the freezing of aqueous solutions plays a crucial role in releasing and transforming nutrients, organic compounds, and trace gases. Freezing processes typically affect biogeochemical cycles and environmental processes by reducing the rate of chemical reactions. However, substantial studies have found that some chemical reactions may accelerate unexpectedly under freezing conditions.
View Article and Find Full Text PDFNicotine levels in flavoured hookah (waterpipe) tobacco products: discrepancies between labelled and measured levels.
Tob Control
January 2025
University of California San Francisco, San Francisco, California, USA.
Background: Hookah tobacco smoking is prevalent among youth and young adults. While health warning labels play a critical role in communicating the health risks of tobacco product use to consumers, compliance with US Federal Regulation's nicotine warning requirements on hookah tobacco packaging is low. Some labelling suggests that consumers are exposed to 'only 0.
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