AI Article Synopsis
- The study aimed to assess how effective topical nepafenac is at increasing pupil diameter in diabetic patients undergoing cataract surgery.
- Two groups of patients (with and without diabetes) had their pupil size measured before and after applying nepafenac to one eye and cyclopentolate to both.
- Results showed that diabetic patients experienced a notable increase in pupil size from the application compared to fellow eyes, indicating that nepafenac has an additional benefit for pupil dilation in these patients.
Article Abstract
Objectives: To evaluate the additive effect of topical nepafenac on pupil diameter (PD) in patients with diabetes mellitus (DM) and cataract.
Methods: This prospective comparative study included the patients having cataract surgery with and without DM. Two consecutive PD measurements were taken using an automatic quantitative pupillometry system (MonPack One, Metrovision). A baseline measurement was taken, then one drop of nepafenac % 0.1 (Nevanac; Alcon, Fort Worth, TX) was instilled only to the eye that will be operated on (study eye). Cyclopentolate 1.0% (Sikloplejin; Abdi İbrahim, İstanbul, Turkey) was instilled to both eyes (study eye/fellow eye) 5 minutes later. The second measurement was taken at 1 hour after this application.
Results: The DM group consisted of 43 patients, and the control group consisted of 39 participants. The baseline PDs of both eyes were similar in the DM group (P=0.070) and the control group (P=0.345). The change in pupil size from baseline to mydriasis was statistically significantly greater in the study eyes (2.69±0.53) than fellow eyes (2.54±0.61) in the DM group (P=0.009), but there was no statistically significant difference in the control group (2.94±0.63 vs. 2.86±0.58). When the groups were compared, the PD changes were similar in the study eyes between groups (P=0.065), while the PD changes in the fellow eyes were lower in the DM group (P=0.017).
Conclusions: Nepafenac has been shown additive effect on pupil dilation in diabetic patients before cataract surgery.
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| http://dx.doi.org/10.1097/ICL.0000000000000657 | DOI Listing |
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