As a fundamental problem in social network analysis, community detection has recently attracted wide attention, accompanied by the output of numerous community detection methods. However, most existing methods are developed by only exploiting link topology, without taking node homophily (i.e., node similarity) into consideration. Thus, much useful information that can be utilized to improve the quality of detected communities is ignored. To overcome this limitation, we propose a new community detection approach based on nonnegative matrix factorization (NMF), namely, homophily preserving NMF (HPNMF), which models not only link topology but also node homophily of networks. As such, HPNMF is able to better reflect the inherent properties of community structure. In order to capture node homophily from scratch, we provide three similarity measurements that naturally reveal the association relationships between nodes. We further present an efficient learning algorithm with convergence guarantee to solve the proposed model. Finally, extensive experiments are conducted, and the results demonstrate that HPNMF has strong ability to outperform the state-of-the-art baseline methods.
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http://dx.doi.org/10.1109/TNNLS.2019.2933850 | DOI Listing |
Microbiome
December 2024
Faculty of Medicine, Human Microbiome Research Program, University of Helsinki, Helsinki, Finland.
Background: Amplicon sequencing of kingdom-specific tags such as 16S rRNA gene for bacteria and internal transcribed spacer (ITS) region for fungi are widely used for investigating microbial communities. So far most human studies have focused on bacteria while studies on host-associated fungi in health and disease have only recently started to accumulate. To enable cost-effective parallel analysis of bacterial and fungal communities in human and environmental samples, we developed a method where 16S rRNA gene and ITS1 amplicons were pooled together for a single Illumina MiSeq or HiSeq run and analysed after primer-based segregation.
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December 2024
Department of Health Disparities Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Black women (BW) experience age-adjusted breast cancer mortality rates that are 40% higher than White women. Although, screening rates for breast cancer are similar between White and Black women, differences in mammography utilization exist among women with lower socioeconomic status (SES). Moreover, perceived everyday discrimination (PED) has been shown to have an inverse relationship on health screening behavior among BW.
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December 2024
GIN, IMN-UMR5293, CEA, CNRS, Université de Bordeaux, Bordeaux, France.
Cerebral microbleeds (CMB) represent a feature of cerebral small vessel disease (cSVD), a prominent vascular contributor to age-related cognitive decline, dementia, and stroke. They are visible as spherical hypointense signals on T2*- or susceptibility-weighted magnetic resonance imaging (MRI) sequences. An increasing number of automated CMB detection methods being proposed are based on supervised deep learning (DL).
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December 2024
Centre for Veterinary Systems Transformation and Sustainability, Clinical Department for Farm Animals and Food System Science, University of Veterinary Medicine Vienna, Vienna, Austria.
The early microbial colonization of the porcine gut is an important priming factor for gut and immune development. Nevertheless, little is known about the composition of microbes that translocate into the ileo-cecal lymph nodes (ICLN) in the neonatal phase. This study aimed to characterize age- and nutrition-related changes in the metabolically active bacterial and fungal composition of the ICLN in suckling and newly weaned piglets.
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December 2024
Dipartimento di Medicina, Chirurgia e Farmacia, University of Sassari, Viale San Pietro 43, Sassari, 07100, Italy.
More than two decades ago, in the central-eastern region of the Mediterranean island of Sardinia, a mountain area was identified where the population displays exceptional longevity, especially among men (the Longevity Blue Zone, LBZ). This community was thoroughly investigated to understand the underlying causes of the phenomenon. The present study analyzed 11 genetic markers previously associated with increased survival in several long-lived populations.
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