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Adaptive Immunity Determines the Cancer Treatment Outcome of Oncolytic Virus and Anti-PD-1.
Bull Math Biol
January 2025
Department of Mathematics, University of Manitoba, 340 UMSU University Centre, Winnipeg, MB, R3T 2N2, Canada.
The immune checkpoint inhibitor, anti-programmed death protein-1 (anti-PD-1), enhances adaptive immunity to kill tumor cells, and the oncolytic virus (OV) triggers innate immunity to clear the infected tumor cells. We create a mathematical model to investigate how the interaction between adaptive and innate immunities under OV and anti-PD-1 affects tumor reduction. For different immunity strength, we create the corresponding virtual baseline patients and cohort patients to decipher the major factors determining the treatment outcome.
View Article and Find Full Text PDFTargeting accuracy of neuronavigation: a comparative evaluation of an innovative wearable AR platform vs. traditional EM navigation.
Front Digit Health
January 2025
Department of Information Engineering, University of Pisa, Pisa, Italy.
Wearable augmented reality in neurosurgery offers significant advantages by enabling the visualization of navigation information directly on the patient, seamlessly integrating virtual data with the real surgical field. This ergonomic approach can facilitate a more intuitive understanding of spatial relationships and guidance cues, potentially reducing cognitive load and enhancing the accuracy of surgical gestures by aligning critical information with the actual anatomy in real-time. This study evaluates the benefits of a novel AR platform, VOSTARS, by comparing its targeting accuracy to that of the gold-standard electromagnetic (EM) navigation system, Medtronic StealthStation S7.
View Article and Find Full Text PDFTele-ophthalmology as an effective triaging tool for acute ophthalmic concerns.
Front Ophthalmol (Lausanne)
January 2025
Bascom Palmer Eye Institute, University of Miami, Miami, FL, United States.
Introduction: The purpose of this study is to determine baseline demographics and utilization trend of an on-demand, synchronous tele-ophthalmology triage program in evaluating acute ophthalmic concerns during the COVID-19 Public Health Emergency.
Methods: Setting: Single-center retrospective chart review of telemedicine visits conducted by ophthalmologists and optometrists from University of Miami's Bascom Palmer Eye Institute. Patient population: 6227 patients comprised 7138 telehealth encounters.
Technical Stroke Regulations Discriminate Pacing Effectiveness During a 5-km Indoor Pool Race.
Int J Sports Physiol Perform
January 2025
M2S Laboratory (Movement, Sport & Health), University Rennes 2, Bruz, France.
Purpose: To investigate technical regulation mechanisms of long-distance swimmers that differentiate optimal pacing strategies and the underlying kinematic parameters.
Methods: Twenty-one national and international swimmers were equipped with a sacrum-worn inertial measurement unit performed during 5000-m indoor French championships. Percentage of critical swimming speed (CSS), stroke rate, stroke length, jerk cost, stroke index, and mechanical proficiency score were computed by lap.
Relativistic CASPT2/RASPT2 Program along with DIRAC Software.
J Chem Theory Comput
January 2025
Department of Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima City, Hiroshima 739-8526, Japan.
Exploring electronic states in actinide compounds is a critical aspect of nuclear science. However, considering relativistic effects and electron correlation in theoretical calculations poses a complex challenge. To tackle this, we developed the CASPT2/RASPT2 program along with the DIRAC program, enabling calculations of electron correlation methods using multiconfigurational perturbation theory with various relativistic Hamiltonians.
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