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Salvage treatment of ruxolitinib for refractory adenovirus-associated hemophagocytic syndrome post-haploidentical allogeneic stem cell transplantation: a case report.
Transl Pediatr
June 2024
Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare complication following hematopoietic stem cell transplantation (HSCT). Currently, there is a lack of consensus recommendations for the treatment of post-transplant HLH. This case report emphasizes the successful utilization of ruxolitinib as a salvage therapy for HLH post-HSCT.
View Article and Find Full Text PDFPediatric Adenovirus-Associated Hemophagocytosis Lymphohistiocytosis - A Single Centre Experience From Eastern India.
Indian Pediatr
September 2024
Department of Pediatrics, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, India.
Acute liver failure and unique challenges of pediatric liver transplantation amidst a worldwide cluster of adenovirus-associated hepatitis.
Am J Transplant
January 2023
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA. Electronic address:
Article Synopsis
- A recent investigation into acute hepatitis cases in southeastern U.S. children found human adenovirus type 41 in all 9 affected individuals, with 56% undergoing molecular genotyping.
- Among these cases, 2 children progressed rapidly to pediatric acute liver failure (PALF) and underwent liver transplantation, which is rare for this condition.
- The study highlights the clinical details, laboratory findings, and the successful post-transplant outcomes, emphasizing the need for early medical intervention and the potential for liver transplantation in severe adenovirus-related cases.
Adenovirus-associated hemophagocytic syndrome in a young child.
World J Pediatr
April 2020
Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, 3333 Binsheng Road, Hangzhou, 310051, China.
Neonatal Adenovirus Infection Complicated by Hemophagocytic Lymphohistiocytosis Syndrome.
Pediatrics
April 2018
Divisions of Critical Care Medicine and.
Two infants with disseminated adenoviral infections are described. Both these infants had a similar clinical course and were also diagnosed with secondary hemophagocytic lymphohistiocytosis (HLH). Previous reports of immunocompromised adults with adenovirus-associated HLH are in the literature; however, this is the first report that we are aware of with this pathology occurring in infants.
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