AI Article Synopsis
- Malignant glioma (MG) is a challenging brain tumor that tends to recur despite aggressive treatments, highlighting the need for better therapeutic options.
- This study investigated the effects of oligo-fucoidan (OF), derived from brown seaweed, on MG cells and found that OF significantly reduced the growth of malignant cells while having a minimal impact on normal astrocyte cells.
- OF works by inhibiting specific proteins involved in DNA methylation and promoting differentiation markers; its effectiveness can be enhanced when used alongside existing clinical DNMT inhibitors like decitabine, suggesting a promising new treatment strategy for MG.
Article Abstract
Malignant glioma (MG) is a poor prognostic brain tumor with inevitable recurrence after multimodality treatment. Searching for more effective treatment is urgently needed. Differentiation induction via epigenetic modification has been proposed as a potential anticancer strategy. Natural products are known as fruitful sources of epigenetic modifiers with wide safety margins. We thus explored the effects of oligo-fucoidan (OF) from brown seaweed on this notion in MG cells including Grade III U87MG cells and Grade IV glioblastoma multiforme (GBM)8401 cells and compared to the immortalized astrocyte SVGp12 cells. The results showed that OF markedly suppress the proliferation of MG cells and only slightly affected that of SVGp12 cells. OF inhibited the protein expressions of DNA methyltransferases 1, 3A and 3B (DNMT1, 3A and 3B) accompanied with obvious mRNA induction of differentiation markers (, , , , and ) both in U87MG and GBM8401 cells. Accordingly, the methylation of , a DNMT3B target gene, was decreased by OF. In combination with the clinical DNMT inhibitor decitabine, OF could synergize the growth inhibition and induction in U87MG cells. Appropriated clinical trials are warranted to evaluate this potential complementary approach for MG therapy after confirmation of the effects in vivo.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780514 | PMC |
| http://dx.doi.org/10.3390/md17090525 | DOI Listing |
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