Plasticity in soft amorphous materials typically involves collective deformation patterns that emerge on intense shearing. The microscopic basis of amorphous plasticity has been commonly established through the notion of "Eshelby"-type events, localized abrupt rearrangements that induce flow in the surrounding material via nonlocal elastic-type interactions. This universal mechanism in flowing disordered solids has been proposed despite their diversity in terms of scales, microscopic constituents, or interactions. Using a numerical particle-based study, we argue that the presence of frictional interactions in granular solids alters the dynamics of flow by nucleating micro shear cracks that continually coalesce to build up system-spanning fracturelike formations on approach to failure. The plastic-to-brittle failure transition is controlled by the degree of frictional resistance which is in essence similar to the role of heterogeneities that separate the abrupt and smooth yielding regimes in glassy structures.
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http://dx.doi.org/10.1103/PhysRevE.100.012908 | DOI Listing |
Cellular plasticity is a hallmark function of cancer, but many of the underlying mechanisms are not well understood. We uncover Caveolin-1, a scaffolding protein that modulates plasma membrane domain organization, as a context-specific regulator of survival signaling in Ewing sarcoma (EwS). Single cell analysis reveals a distinct subpopulation of EwS cells, which highly express the cell surface marker CD99 as well as Caveolin-1.
View Article and Find Full Text PDFFront Bioeng Biotechnol
December 2024
Vascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Introduction: Magnetic nanoparticles (MNPs), particularly iron oxide nanoparticles (IONPs), are renowned for their superparamagnetic behavior, allowing precise control under external magnetic fields. This characteristic makes them ideal for biomedical applications, including diagnostics and drug delivery. Superparamagnetic IONPs, which exhibit magnetization only in the presence of an external field, can be functionalized with ligands for targeted affinity diagnostics.
View Article and Find Full Text PDFMicrobiome
December 2024
State Key Laboratory of Nutrient Use and Management, Key Laboratory of Plant-Soil Interactions, College of Resources and Environmental Sciences, Ministry of Education, National Academy of Agriculture Green Development, China Agricultural University, Beijing, 100193, China.
Background: Planetary plastic pollution poses a major threat to ecosystems and human health in the Anthropocene, yet its impact on biogeochemical cycling remains poorly understood. Waterlogged rice paddies are globally important sources of CH. Given the widespread use of plastic mulching in soils, it is urgent to unravel whether low-density polyethylene (LDPE) will affect the methanogenic community in flooded paddy soils.
View Article and Find Full Text PDFBMC Oral Health
December 2024
Department of Restorative Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Objective: To assess the color stability and surface roughness of bioactive resin-based composite following exposure to coffee staining and brushing with whitening toothpastes.
Methods: Disk-shaped specimens of Filtek Z250 (FZ), Beautifil Flow Plus (BFP), Activa Presto (AP), and Fuji II LC (FII) were stained with coffee and then brushed with one of three toothpastes, conventional (C-TP), non-peroxide whitening (W-TP) or hydrogen peroxide-containing whitening toothpaste (HPW-TP) for 10 000 cycles. Changes in color (ΔE) and surface roughness were measured.
J Pharm Sci
December 2024
Undergraduate student, Faculty of Pharmacy, Suleyman Demirel University, Isparta, Türkiye.
Lacosamide (LCM) selectively increases the slow inactivation of voltage-gated sodium channels (VGSCs) and is a N-methyl D-aspartate acid (NMDA) receptor glycine site antagonist. Therefore, it can be used in dryness-related hyperexcitability of corneal cold receptor nerve terminals. Ocular in-situ gels remain in liquid form until they reach the target site, where they undergo a sol-gel transformation in response to specific stimuli.
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