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Convergent Evolution of Mucosal Immune Responses at the Buccal Cavity of Teleost Fish. | LitMetric

Convergent Evolution of Mucosal Immune Responses at the Buccal Cavity of Teleost Fish.

iScience

Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei 430070, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong 266071, China. Electronic address:

Published: September 2019

AI Article Synopsis

Article Abstract

The buccal mucosa (BM) is a critical first line of defense in terrestrial animals. To gain further insights into the evolutionary origins and primordial roles of BM in teleosts here we show that rainbow trout, a teleost fish, contains a diffuse mucosal associated lymphoid tissue (MALT) within its buccal cavity. Upon parasite infection, a fish immunoglobulin specialized in mucosal immunity (sIgT) was induced to a high degree, and parasite-specific sIgT responses were mainly detected in the buccal mucus. Moreover, we show that the trout buccal microbiota is prevalently coated with sIgT. Overall our findings revealed that the MALT is present in the BM of a non-tetrapod species. As fish IgT and mucus-producing cells are evolutionarily unrelated to mammalian IgA and salivary glands, respectively, our findings indicate that mucosal immune responses in the BM of teleost fish and tetrapods evolved through a process of convergent evolution.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734174PMC
http://dx.doi.org/10.1016/j.isci.2019.08.034DOI Listing

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