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Unusual case of retinal arterial branch occlusion: possible variant of Sneddon syndrome.
Arch Soc Esp Oftalmol (Engl Ed)
May 2024
Servicio de Oftalmología, Hospital Clínico Universitario, Valladolid, Spain. Electronic address:
Sneddon's syndrome (SS) manifests through multiple strokes and livedo reticularis. Livedoid vasculopathy (VL) is characterized by a long history of foot and leg ulceration and histopathology indicating a thrombotic process. Arterial retinal branch occlusion is described in a 52-year-old male with VL.
View Article and Find Full Text PDFEssential thrombocythemia manifesting as livedoid and purpuric skin lesions: Report of two cases and literature review.
J Cutan Pathol
August 2023
Department of Dermatology, Hospital Clínico Lozano Blesa, Zaragoza, Spain.
Essential thrombocythemia is a chronic myeloproliferative syndrome which usually runs its course as an asymptomatic elevated platelet count. Cutaneous manifestations secondary to microcirculation abnormalities are rare but can represent a helpful diagnostic clue in order to prevent major thromboembolic events. We report two cases of heterogeneous livedoid and "net-like" skin lesions in the context of essential thrombocythemia with identical histopathologic findings (medium-sized blood vessels with luminal obliteration by eosinophilic material, mostly positive for the platelet marker CD61, without vasculitis).
View Article and Find Full Text PDFNo antibody response in cutaneous manifestations associated with COVID-19: An observational study of 64 cases with microbiological and clinical characterization.
Dermatol Ther
November 2021
Department of Dermatology, Lozano Blesa University Clinical Hospital, Zaragoza, Spain.
Background: The microbiological diagnosis of skin lesions related to COVID-19 is not well known.
Objective: Perform a microbiological diagnosis in COVID19-related cutaneous manifestations.
Methods: A cross-sectional study was performed with 64 patients with cutaneous manifestations associated with COVID-19 who underwent serological and nasopharyngeal reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2.
Expanding spectrum of DADA2: a review of phenotypes, genetics, pathogenesis and treatment.
Clin Rheumatol
October 2021
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Deficiency of adenosine deaminase 2 (DADA2) is a monogenic disease caused by biallelic mutations in ADA2 gene (previously CECR1). The aim of this review was to describe the clinical phenotypes, genetics, pathogenesis and treatment of DADA2. ADA2 is highly expressed on myeloid cells and deficiency leads to polarisation of macrophages to an M1 inflammatory type and activation of neutrophils.
View Article and Find Full Text PDFClinical manifestation and disease progression in COVID-19 infection.
J Chin Med Assoc
January 2021
Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Coronavirus disease 2019 (COVID-19) is mainly an infectious disease of the respiratory system transmitted through air droplets, and pulmonary symptoms constitute main presentations of this disease. However, COVID-19 demonstrates a clinically diverse manifestation ranging from asymptomatic presentation to critically illness with severe pneumonia, acute respiratory distress syndrome, respiratory failure, or multiple organ failure. Accumulating evidences demonstrated that COVID-19 has extrapulmonary involvement, including neurological, smelling sensation, cardiovascular, digestive, hepatobiliary, renal, endocrinologic, dermatologic system, and others.
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