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Successful Treatment of Tenofovir Alafenamide-Induced Lactic Acidosis: A Case Report.
J Pharm Pract
October 2023
Department of Medicine, Division of Gastroenterology & Hepatology - NYU Langone Health, New York, NY, USA.
Nucleoside or nucleotide analogues (NAs) have the potential to cause lactic acidosis by inhibiting DNA polymerase-γ of human mitochondria and impairing aerobic metabolism. Patients may be asymptomatic, have mild non-specific symptoms, or present in multisystem organ failure. There is a paucity of data to guide management of life-threatening lactic acidosis due to NA therapy.
View Article and Find Full Text PDFAn unexpected adverse effect: Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide-induced cholestasis.
Antivir Ther
May 2022
Infectious Diseases Department, 16493Hospital Clinic of Barcelona, Barcelona, Spain.
Bictegravir/emtricitabine/tenofovir alafenamide-induced acute pancreatitis: a case report.
Int J STD AIDS
September 2020
Department of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy.
We report here the case of a 32-year-old male with recent diagnosis of HIV that, 45 days after starting a single tablet regimen co-formulated with bictegravir, emtricitabine and tenofovir alafenamide (BIC/FTC/TAF), experienced severe epigastric pain radiating to the back, nausea, episodes of non-bloody non-bilious vomiting and anorexia. Laboratory examination showed a rise in lipase with no alterations in serum transaminases. Abdominal ultrasound revealed a non-homogeneous structure of the pancreatic parenchyma.
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Department of Internal Medicine, Maimonides Medical Center, New York, NY.
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