Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760969 | PMC |
| http://dx.doi.org/10.1039/c9sm01314h | DOI Listing |
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