An unexpected case of prosthetic vascular graft infection.

Infect Drug Resist

Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Bordeaux, Groupe Hospitalier Pellegrin, Bordeaux, F-33000, France.

Published: August 2019

is a wild rabbit pathogen causing bacteremia rarely reported in humans, with only three cases published so far, including one lymphadenitis and two endocarditis cases. Here, we report the case of a 66-year-old man who suffered from acute renal failure due to a membranoproliferative glomerulonephritis. Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) showed diffuse FDG uptake around the aortobifemoral graft with no indication of infection. A white blood cell scan showed an accumulation of labeled neutrophils on the left femoral part of the graft. The patient underwent surgery and an abscess around the left iliac part of the graft was found intraoperatively. Intraoperative samples were all negative, but 16S rRNA gene-based PCR was positive, and the sequence was positioned among the species cluster. Specific PCRs targeting EL/60, B and A genes were performed and led to the identification of . Accordingly, indirect immunofluorescence serological analyses were positive for and . The patient had a history of regularly hunting wild rabbits. He was treated with 100 mg of doxycycline twice a day for six months and his renal function significantly improved with no sign of persistent infection. This case highlights the contribution of serology assays and molecular-based methods in prosthetic vascular graft infection diagnosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689760PMC
http://dx.doi.org/10.2147/IDR.S206805DOI Listing

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