Opportunities for Electroceuticals in Epilepsy.

Trends Pharmacol Sci

Sydney Medical School and Brain and Mind Centre, The University of Sydney, Sydney, NSW 2006, Australia; Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW 2050, USA.

Published: October 2019

Epilepsy is a neurological disorder that affects ∼1% of the world population. Nearly 30% of epilepsy patients suffer from pharmacoresistant epilepsy that cannot be treated with antiepileptic drugs. Depending on seizure type, a diverse range of therapies are available, including surgery, vagus nerve stimulation, and deep brain stimulation. We review the sensing and stimulation technologies most used in neurological disorders, and provide a vision of minimally invasive electroceuticals to enable accurate forecasting of epileptic seizures and therapy. The use of such systems could potentially help patients to prevent injuries and, in combination with an intervention mechanism, could provide a method of suppressing seizures in epileptic patients.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tips.2019.08.001DOI Listing

Publication Analysis

Top Keywords

opportunities electroceuticals
4
epilepsy
4
electroceuticals epilepsy
4
epilepsy epilepsy
4
epilepsy neurological
4
neurological disorder
4
disorder ∼1%
4
∼1% population
4
population 30%
4
30% epilepsy
4

Similar Publications

Cancer is a pernicious and pressing medical problem; moreover, it is a failure of multicellular morphogenesis that sheds much light on evolutionary developmental biology. Numerous classes of pharmacological agents have been considered as cancer therapeutics and evaluated as potential carcinogenic agents; however, these are spread throughout the primary literature. Here, we briefly review recent work on ion channel drugs as promising anti-cancer treatments and present a systematic review of the known cancer-relevant effects of 109 drugs targeting ion channels.

View Article and Find Full Text PDF

Electroceuticals for peripheral nerve regeneration.

Biofabrication

September 2022

Division of Plastic and Reconstructive Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.

Electroceuticals provide promising opportunities for peripheral nerve regeneration, in terms of modulating the extensive endogenous tissue repair mechanisms between neural cell body, axons and target muscles. However, great challenges remain to deliver effective and controllable electroceuticals via bioelectronic implantable device. In this review, the modern fabrication methods of bioelectronic conduit for bridging critical nerve gaps after nerve injury are summarized, with regard to conductive materials and core manufacturing process.

View Article and Find Full Text PDF

In the name of electroceuticals, bioelectronic devices have transformed and become essential for dealing with all physiological responses. This significant advancement is attributable to its interdisciplinary nature from engineering and sciences and also the progress in micro and nanotechnologies. Undoubtedly, in the future, bioelectronics would lead in such a way that diagnosing and treating patients' diseases is more efficient.

View Article and Find Full Text PDF

Placement of the clinical vagus nerve stimulating cuff is a standard surgical procedure based on anatomical landmarks, with limited patient specificity in terms of fascicular organization or vagal anatomy. As such, the therapeutic effects are generally limited by unwanted side effects of neck muscle contractions, demonstrated by previous studies to result from stimulation of (1) motor fibers near the cuff in the superior laryngeal and (2) motor fibers within the cuff projecting to the recurrent laryngeal. Conventional non-invasive ultrasound, where the transducer is placed on the surface of the skin, has been previously used to visualize the vagus with respect to other landmarks such as the carotid and internal jugular vein.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!