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Efficacy of Lurasidone in First-Episode Psychosis: Patient Phenotypes, Dosage, and Recommendations from an Expert Panel.
Neurol Ther
January 2025
Department of Psychiatry, Faculty of Medicine, Mental Health Unit, Virgen del Rocio University Hospital, Translational Psychiatry Group, IBiS-CSIC, CIBERSAM, University of Seville, Seville, Spain.
Introduction: For patients with psychosis, early, intensive therapeutic intervention is thought to improve long-term outcomes. Furthermore, patients with a first-episode psychosis (FEP) who experience a good early response to antipsychotic medication show a clinical and functional benefit over the longer term if they continue low-dose antipsychotic treatment. Lurasidone is an atypical antipsychotic agent which is approved in Europe for the treatment of schizophrenia in adults and adolescents (13-17 years).
View Article and Find Full Text PDFIntroduction: Society commonly believes that research knowledge is complementary to public decision-making. This study aimed to understand the perspectives and implications of dementia researchers communicating with policymakers and public research decision-makers (public officials).
Methods: This study uses 24 questions from an anonymous, online survey, which was received by 392 members of nine European, Latin American, and United States medical researcher associations/networks in the fields of age-related neurological degeneration and dementia medicine.
First isolation of the Sindbis virus in mosquitoes from southwestern Spain reveals a new recent introduction from Africa.
One Health
June 2025
Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Sindbis virus (SINV), is an of the family . This zoonotic arbovirus is transmitted by mosquitoes, primarily from the genus, with bird species acting as amplifying vertebrate hosts. Occasionally it can also affect humans that are accidental hosts.
View Article and Find Full Text PDFIntroduction: Anthropometric, demographic, genetic, and clinical features may affect cognitive, behavioral, and functional decline, while clinical trials seldom consider minimal clinically important differences (MCIDs) in their analyses.
Methods: MCIDs were reviewed taking into account features that may affect cognitive, behavioral, or functional decline in clinical trials of new disease-modifying therapies.
Results: The higher the number of comparisons of different confounders in statistical analyses, the lower values will be significant.
A Comparative Study of Laparoscopic Skills Between Novices and Experts: How to Steepen the Learning Curve.
Cureus
December 2024
Urology, Université Saint-Joseph, Hôtel-Dieu de France University Hospital, Beirut, LBN.
Introduction and aim Laparoscopic surgery has revolutionized the field of surgery over the past few decades. The learning curve in laparoscopy is known to be slow, flat, and complex. This study aims to conduct a comparative analysis of laparoscopic skills, specifically focusing on suturing, knot tying, and needle handling, between novices and experts.
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