Introduction: Previous results have indicated that CXCR4 is an oncogene in several types of human tumors including renal cell carcinoma (RCC). However, the correlation between CXCR4 expression and clinicopathological characteristics of RCC remains unclear.
Materials And Methods: We conducted a meta-analysis to quantitatively evaluate the association of CXCR4 expression with the incidence of RCC and clinicopathological characteristics. Final analysis of 1203 patients with RCC from 14 eligible studies was performed.
Results: We observed that CXCR4 expression is significantly higher in RCC than in normal renal tissue, and the pooled OR from 7 studies including 435 RCC and 297 normal renal tissues was OR = 46.23, 95% CI = 7.18-297.69, p < 0.0001. CXCR4 expression is not associated with gender status and clinical stages. However, CXCR4 expression was significantly associated with pathological grades, metastatic status, and overall survival in patients with RCC.
Discussion: These results indicate that CXCR4 expression is associated with increased risk, progression, and prognosis for patients with RCC. The determination of CXCR4 expression may provide a biomarker for tumor risk evaluation, progression, and prognosis of patients with RCC.
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| http://dx.doi.org/10.1016/j.ijsu.2019.08.021 | DOI Listing |
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