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Differential distribution of some extracellular matrix fibers in an experimentally denervated rat megaileum.
Micron
June 2008
Laboratory of Cell Biology, Department of Pathology, The University of São Paulo School of Medicine, São Paulo, Brazil.
Absence of enteric neurons is associated with thickening of the intestinal muscularis externa in Chagas' disease. The thickening is due to hyperplasia and hypertrophy of the smooth muscle cells and increased extracellular matrix components. The influence of the nervous system on the structure of the smooth muscle cells and its associated matrix has been poorly investigated.
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